CDC45 - cell division cycle 45 Gene

Also Known as CDC45L; MGORS7; CDC45L2; PORC-PI-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8318

About CDC45

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,479,466-19,520,612 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and is associated with 3 phenotypes. Biased expression in testis (RPKM 11.5), bone marrow (RPKM 6.8) and 11 other tissues.

Summary

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA Polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA Polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA Polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

CDC45 Products (4)

mRNA	Protein	Name
NM_001178010.2	NP_001171481.1	cell division control protein 45 homolog isoform 1
NM_001178011.2	NP_001171482.1	cell division control protein 45 homolog isoform 3
NM_001369291.1	NP_001356220.1	cell division control protein 45 homolog isoform 4 precursor
NM_003504.5	NP_003495.1	cell division control protein 45 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10518787	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	29257953	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21383955	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC45 Protein Structure

CDC45

0
100
200
300
400
500
566 a.a.

Protein Preferred Names	Protein Names
cell division control protein 45 homolog	CDC45 cell division cycle 45 homolog

CDC45 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC45	O75419	RAB4B	Homo sapiens	P61018	Validated Y2H	32296183
Intra	CDC45	O75419	RAB4B	Homo sapiens	P61018	Y2H Array	32296183
Intra	CDC45	O75419	RAB4B	Homo sapiens	P61018	Y2H Prey Pooling	32296183
Intra	CDC45	O75419	CLSPN	Homo sapiens	Q9HAW4	Pull Down	23910567
Intra	CDC45	O75419	CLSPN	Homo sapiens	Q9HAW4	Anti Bait CoIP	23910567
Intra	CDC45	O75419	CLSPN	Homo sapiens	Q9HAW4	Anti Tag CoIP	33961781
Intra	CDC45	O75419	TOPBP1	Homo sapiens	Q92547	Pull Down	17887956
Intra	CDC45	O75419	TOPBP1	Homo sapiens	Q92547	Anti Bait CoIP	17887956
Intra	CDC45	O75419	CDKN1A	Homo sapiens	P38936	PLA	25241761
Intra	CDC45	O75419	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	CDC45	O75419	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	CDC45	O75419	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	CDC45	O75419	RPA2	Homo sapiens	P15927	Pull Down	23910567
Intra	CDC45	O75419	RPA2	Homo sapiens	P15927	Anti Bait CoIP	23910567
Intra	CDC45	O75419	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CDC45	O75419	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CDC45	O75419	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CDC45	O75419	GINS4	Homo sapiens	Q9BRT9	Anti Tag CoIP	33961781
Intra	CDC45	O75419	GINS4	Homo sapiens	Q9BRT9	BiFC	19805216
Intra	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Array	31515488
Intra	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	32296183
Intra	CDC45	O75419	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC45 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83413	CDC45 Antibody (YA3158)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 7	MGORS7 Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Rapadilino Syndrome	Absent Thumbs, Dislocated Joints, Long Face With Narrow Palpebral Fissures, Long Slender Nose, Arched Palate Radial And Patellar Aplasia Radial And Patellar Hypoplasia RAPADILINOS
Baller-Gerold Syndrome	BGS Craniosynostosis With Radial Defects Craniosynostosis-Radial Aplasia Syndrome Craniosynostosis Radial Aplasia Syndrome
Ichthyosis, Congenital, Autosomal Recessive 9	Autosomal Recessive Congenital Ichthyosis 9 ARCI9 Ichthyosis, Congenital, Autosomal Recessive, Type 9
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181723	Anticancer agent 304		/	Unkown
HY-182752	CDK1-IN-9		/	Unkown
HY-RS02306	CDC45 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20873	Cdc45 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27390	Cdc45 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDC45	VGNC	VGNC:39007
Mus musculus	CDC45	MGD	MGI:1338073
Rattus norvegicus	CDC45	RGD	RGD:1590928
Bos taurus	CDC45	VGNC	VGNC:27079
Felis catus	CDC45	VGNC	VGNC:60662
Macaca mulatta	CDC45	VGNC	VGNC:70800
Others	CDC45	NCBI