TOPBP1 - DNA topoisomerase II binding protein 1 Gene

Also Known as Dpb11; TOP2BP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11073

About TOPBP1

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,600,238-133,661,941 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in testis (RPKM 16.9), bone marrow (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes a binding protein which interacts with the C-terminal region of Topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of Topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]

TOPBP1 Products (2)

mRNA	Protein	Name
NM_001363889.2	NP_001350818.1	DNA topoisomerase 2-binding protein 1 isoform 2
NM_007027.4	NP_008958.2	DNA topoisomerase 2-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin-protein adaptor activity	IDA IDA: Inferred from direct assay	17575048	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17006541	GOA
enables phosphorylation-dependent protein binding	IDA IDA: Inferred from direct assay	17575048	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12773567	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	21777809	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	17575048	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	12773567	GOA
involved in DNA replication checkpoint signaling	IDA IDA: Inferred from direct assay	21482717	GOA
involved in broken chromosome clustering	IDA IDA: Inferred from direct assay	37165191	GOA
involved in chromosome organization	IDA IDA: Inferred from direct assay	35121901	GOA
involved in double-strand break repair via alternative nonhomologous end joining	IDA IDA: Inferred from direct assay	37674080	GOA
involved in double-strand break repair via classical nonhomologous end joining	IDA IDA: Inferred from direct assay	31135337	GOA
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	26811421	GOA
involved in protein localization to site of double-strand break	IDA IDA: Inferred from direct assay	26811421	GOA
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	12773567	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of BRCA1-B complex	IPI IPI: Inferred from physical interaction	16391231	GOA
located in PML body	IDA IDA: Inferred from direct assay	12773567	GOA
is active in chromosome	IDA IDA: Inferred from direct assay	35121901	GOA
located in chromosome	IDA IDA: Inferred from direct assay	21659603	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	21777809	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	26811421	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOPBP1 Protein Structure

BRCT

PTCB-BRCT

BRCT

PTCB-BRCT

BRCT

0
300
600
900
1200
1522 a.a.

Protein Preferred Names	Protein Names
DNA topoisomerase 2-binding protein 1	DNA topoisomerase II-beta-binding protein 1

TOPBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TOPBP1	Q92547	E2	Human papillomavirus	P03120	Anti Tag CoIP	17006541
Intra	TOPBP1	Q92547	E2	Human papillomavirus	P03120	CoIP	11934899
Intra	TOPBP1	Q92547	E2F1	Homo sapiens	Q01094	Pull Down	14576432
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Anti Tag CoIP	17913746
Intra	TOPBP1	Q92547	E2F1	Homo sapiens	Q01094	Anti Bait CoIP	17006541
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Pull Down	17913746
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Anti Bait CoIP	17913746
Intra	TOPBP1	Q92547	CDC45	Homo sapiens	O75419	Anti Bait CoIP	17887956
Intra	TOPBP1	Q92547	TCF20	Homo sapiens	Q9UGU0	Y2H	17913746
Intra	TOPBP1	Q92547	E2F1	Homo sapiens	Q01094	Pull Down	17006541

Cross: Cross-species interaction Intra: Intraspecies interaction

TOPBP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87126	TopBP1 Antibody (YA6819)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Pulmonary Venoocclusive Disease	Pulmonary Veno-Occlusive Disease Obstructive Disease Of The Pulmonary Veins Pvod Isolated Pulmonary Venous Sclerosis Venous Form Of Primary Pulmonary Hypertension Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160409	TopBP1-IN-1		98.35%	Unkown
HY-RS14901	TOPBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TOPBP1	VGNC	VGNC:49635
Bos taurus	TOPBP1	VGNC	VGNC:49585
Macaca mulatta	TOPBP1	VGNC	VGNC:79061
Rattus norvegicus	TOPBP1	RGD	RGD:1562949
Felis catus	TOPBP1	VGNC	VGNC:66452
Mus musculus	TOPBP1	MGD	MGI:1920018
Others	TOPBP1	NCBI