Pias3 - protein inhibitor of activated STAT, 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83614

Summary

Enables Potassium Channel regulator activity; protein C-terminus binding activity; and protein N-terminus binding activity. Involved in positive regulation of gene expression; positive regulation of membrane potential; and response to hormone. Located in dendrite; nucleus; and synapse. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Apr 2022]

Pias3 Products (1)

mRNA Protein Name
NM_031784.3 NP_113972.2 E3 SUMO-protein ligase PIAS3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
17486098 RGD
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
9565597 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10794667 RGD
enables transmembrane transporter binding IDA
IDA: Inferred from direct assay
9565597 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
9565597 RGD
involved in positive regulation of membrane potential IDA
IDA: Inferred from direct assay
9565597 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
11133009 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
17486098 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS3

  • E3 SUMO-protein transferase PIAS3

  • KChAP

  • potassium channel regulatory protein KChAP

  • potassium channel-associated protein

  • protein inhibitor of activated STAT protein 3

Pias3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pias3 O70260 Grik2 Rattus norvegicus P42260
Y2H
17486098
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10475 PIAS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21688 Pias3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28206 Pias3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pias3 NCBI NCBI:10401