Grik2 - glutamate ionotropic receptor kainate type subunit 2 Gene

Also Known as GluK2; GluR6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54257

Summary

Enables several functions, including PDZ domain binding activity; enzyme binding activity; and kainate selective glutamate receptor activity. Involved in several processes, including negative regulation of glutamatergic synaptic transmission; positive regulation of neuron apoptotic process; and regulation of JNK cascade. Located in dendrite cytoplasm; perikaryon; and terminal bouton. Is integral component of plasma membrane. Part of ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive non-syndromic intellectual disability. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Grik2 Products (1)

mRNA Protein Name
NM_019309.2 NP_062182.1 glutamate receptor ionotropic, kainate 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
1127911 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
12597860 RGD
enables glutamate receptor activity IDA
IDA: Inferred from direct assay
10627597 RGD
enables glutamate-gated calcium ion channel activity IDA
IDA: Inferred from direct assay
7681676 RGD
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
1322826 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
1648177 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
1648177 RGD
enables kainate selective glutamate receptor activity IDA
IDA: Inferred from direct assay
1648177 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9808460 RGD
enables scaffold protein binding IDA
IDA: Inferred from direct assay
12597860 RGD
enables ubiquitin conjugating enzyme binding IPI
IPI: Inferred from physical interaction
17486098 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17486098 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
1648177 RGD
involved in modulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
12597860 RGD
involved in negative regulation of synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
16420445 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11152698 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17639597 RGD
involved in receptor clustering IDA
IDA: Inferred from direct assay
9808460 RGD
involved in regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
11152698 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15844209 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9808460 RGD
located in dendrite cytoplasm IDA
IDA: Inferred from direct assay
15844209 RGD
part of ionotropic glutamate receptor complex IDA
IDA: Inferred from direct assay
10627597 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
15844209 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
8163463 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15844209 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor ionotropic, kainate 2

  • gluR-6

  • glutamate receptor 6

  • glutamate receptor, ionotropic, kainate 2

Grik2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Grik2 P42260 Map3k11 Rattus norvegicus Q66HA1
Anti Bait CoIP
22483987
Intra
Grik2 P42260 Sumo1 Rattus norvegicus Q5I0H3
Anti Bait CoIP
17486098
Intra
Grik2 P42260 Sumo1 Rattus norvegicus Q5I0H3
Anti Bait CoIP
22483987
Intra
Grik2 P42260 Sumo1 Rattus norvegicus Q5I0H3
Anti Tag CoIP
22089239
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
Solution Sedimentation
19465914
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
Solution Sedimentation
17115050
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
Crosslink
20404149
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
GMS
25119039
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
X-Ray Diffraction
19465914
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
X-Ray Diffraction
17115050
Intra
Grik2 P42260 Ube2i Rattus norvegicus P63281
Y2H
17486098
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
Solution Sedimentation
19617541
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
3D-EM
25119039
Intra
Grik2 P42260 Grik5 Rattus norvegicus Q63273
FRET
34706237
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
Light Scattering
19465914
Intra
Grik2 P42260 Grik2 Rattus norvegicus P42260
GMS
19465914
Intra
Grik2 P42260 Pias3 Rattus norvegicus O70260
Anti Bait CoIP
17486098
Intra
Grik2 P42260 Ube2i Rattus norvegicus P63281
Anti Bait CoIP
17486098
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05799 GRIK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05802 GRIK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20416 Grik2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26925 Grik2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grik2 NCBI NCBI:2898