GRIK2 - glutamate ionotropic receptor kainate type subunit 2 Gene

Also Known as EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2; NEDLAS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2898

About GRIK2

Cytogenetic location: 6q16.3 Genomic coordinates (GRCh38): 6:101,393,708-102,070,083 (from NCBI)

This gene has 41 transcripts (splice variants), 333 orthologues, 17 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 2.7), heart (RPKM 0.6) and 5 other tissues.

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]

GRIK2 Products (3)

mRNA	Protein	Name
NM_001166247.1	NP_001159719.1	glutamate receptor ionotropic, kainate 2 isoform 3 precursor
NM_021956.5	NP_068775.1	glutamate receptor ionotropic, kainate 2 isoform 1 precursor
NM_175768.3	NP_786944.1	glutamate receptor ionotropic, kainate 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellularly glutamate-gated ion channel activity	IMP IMP: Inferred from mutant phenotype	28180184	GOA
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	7536611	GOA
enables glutamate-gated receptor activity	IMP IMP: Inferred from mutant phenotype	34375587	GOA
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	15537878	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15537878	GOA
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	15537878	GOA
involved in regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	15537878	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14511640	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	34375587	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIK2 Protein Structure

ANF_receptor

Lig_chan-Glu_bd

Lig_chan

0
200
400
600
800
908 a.a.

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, kainate 2	GluK2(alt_5'UTR)

Recombinant GRIK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75156	GRIK2 Protein, Human (HEK293, hFc)	Q13002/NP_001159719.1 (T32-P561)	≥ 95%, as determined by reducing SDS-PAGE.

GRIK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82960	GRIK2 Antibody (YA2705)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures	NEDLAS
Intellectual Developmental Disorder, Autosomal Recessive 6	MRT6 Autosomal Recessive Intellectual Developmental Disorder 6
Cerebral Visual Impairment	Cortical Visual Impairment Central Visual Impairment Visual Cortex Disorder
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Brugada Syndrome 3	BRGDA3 Brugada Syndrome, Type 3
Non-Syndromic X-Linked Intellectual Disability 90	Mrx90
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Spherocytosis, Type 1	Hereditary Spherocytosis Type 1 SPH1 Hs1 Spherocytosis, Hereditary, 1 Sph Hs Hereditary Spherocytosis 1 Spherocytosis 1
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05799	GRIK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05802	GRIK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20416	Grik2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26925	Grik2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GRIK2	RGD	RGD:2733
Mus musculus	GRIK2	MGD	MGI:95815
Bos taurus	GRIK2	VGNC	VGNC:29643
Felis catus	GRIK2	VGNC	VGNC:67468
Canis familiaris	GRIK2	VGNC	VGNC:41487
Macaca mulatta	GRIK2	VGNC	VGNC:81075
Others	GRIK2	NCBI