GRIK2 Antibody (YA2705)
(Synonyms: EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2)
Based on 1 Customer Validation
GRIK2 Antibody (YA2705) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRIK2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:50-1:100 |
Product Details
GRIK2 Antibody (YA2705) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GRIK2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 103 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 103 kDa
Entrez Gene: 2898 Human ; 14807 Mouse ;
SwissProt: Q13002 Human ; Q13003 Human ; B1AS29 Mouse ;
OMIM: 611092 Human
A synthesized peptide derived from human GRIK2 aa100-150/908.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GRIK2 is an Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses[1].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Postsynaptic cell membrane; Multi-pass membrane protein
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Isoforms & Post-Translational Modification
Q13002 has 7 isomers: Q13002-1: 102583 Da (predicted); Q13002-2: 97981 Da (predicted); Q13002-3: 66108 Da (predicted); Q13002-4: 93966 Da (predicted); Q13002-5: 100243 Da (predicted); Q13002-6: 77054 Da (predicted); Q13002-7: 77112 Da (predicted).
Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity);Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity);Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation -
Subunit
Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Can form functional heteromeric receptors with GRIK2. Interacts with PRKCABP. Interacts with NETO2
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SwissProt ID
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Synonyms
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2
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Research Field
Neuroscience
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