MAP3K11 - Map3k11 mitogen-activated protein kinase kinase kinase 11 Gene

Also Known as Mlk3; RHOE; Mlk-3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309168

Summary

Enables ATP binding activity; JUN kinase kinase kinase activity; and enzyme binding activity. Involved in several processes, including JNK cascade; positive regulation of JNK cascade; and positive regulation of neuron apoptotic process. Predicted to be located in microtubule. Predicted to be active in centrosome. Orthologous to human MAP3K11 (mitogen-activated protein kinase kinase kinase 11). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K11 Products (1)

mRNA Protein Name
NM_001013150.1 NP_001013168.1 mitogen-activated protein kinase kinase kinase 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables ATP binding IDA
IDA: Inferred from direct assay
11438570 RGD
enables JUN kinase kinase kinase activity IDA
IDA: Inferred from direct assay
17064355 RGD
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
11438570 RGD
enables mitogen-activated protein kinase kinase binding IPI
IPI: Inferred from physical interaction
14575811 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17348686 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17161586 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
17161586 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
15680699 RGD
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
17064355 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15069087 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11416147 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
17161586 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11438570 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 11

  • mixed lineage kinase 3

MAP3K11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Map3k11 Q66HA1 Grik2 Rattus norvegicus P42260
Anti Bait CoIP
22483987
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08048 MAP3K11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20638 Map3k11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27147 Map3k11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MAP3K11 NCBI NCBI:4296