TTC5 - tetratricopeptide repeat domain 5 Gene

Also Known as Strap; NEDCAFD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91875

About TTC5

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,286,227-20,305,951 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.6), thyroid (RPKM 6.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTC5 Products (1)

mRNA Protein Name
NM_138376.3 NP_612385.2 tetratricopeptide repeat protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ribosome binding IMP
IMP: Inferred from mutant phenotype
31727855 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
31727855 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
31727855 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTC5 Protein Structure

TPR_11

TPR_11: TPR repeat (87 - 130)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

tetratricopeptide repeat protein 5

  • TPR repeat protein 5

TTC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TTC5 Q8N0Z6 HDX Homo sapiens Q7Z353
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 HDX Homo sapiens Q7Z353
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 CAMK2B Homo sapiens Q13554
Y2H Prey Pooling
25416956
Intra
TTC5 Q8N0Z6 CAMK2B Homo sapiens Q13554
Validated Y2H
25416956
Intra
TTC5 Q8N0Z6 CAMK2B Homo sapiens Q13554
Y2H Array
25416956
Intra
TTC5 Q8N0Z6 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
Intra
TTC5 Q8N0Z6 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 CAMK2B Homo sapiens Q13554-3
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 CAMK2B Homo sapiens Q13554-3
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 CAMK2D Homo sapiens Q13557-8
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 CAMK2D Homo sapiens Q13557-8
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 CAMK2G Homo sapiens Q13555-5
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 CAMK2G Homo sapiens Q13555-5
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 CAMK2A Homo sapiens Q9UQM7
Validated Y2H
32296183
Intra
TTC5 Q8N0Z6 CAMK2A Homo sapiens Q9UQM7
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 CAMK2A Homo sapiens Q9UQM7
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 CAVIN1 Homo sapiens Q6NZI2
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 CAVIN1 Homo sapiens Q6NZI2
Y2H Prey Pooling
32296183
Intra
TTC5 Q8N0Z6 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
TTC5 Q8N0Z6 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
TTC5 Q8N0Z6 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Cerebral Atrophy And Variable Facial Dysmorphism

  • NEDCAFD
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Pseudobulbar Palsy

  • Pseudobulbar Paralysis
Tubulinopathy

  • Tubulinopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15216 TTC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TTC5 RGD RGD:1311284
Canis familiaris TTC5 VGNC VGNC:47960
Mus musculus TTC5 MGD MGI:2683584
Felis catus TTC5 VGNC VGNC:66674
Bos taurus TTC5 VGNC VGNC:36479
Macaca mulatta TTC5 VGNC VGNC:79190
Others TTC5 NCBI