PPP1R14A - protein phosphatase 1 regulatory inhibitor subunit 14A Gene

Also Known as CPI17; CPI-17; PPP1INL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 94274

About PPP1R14A

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,251,237-38,256,374 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues and 3 paralogues. Broad expression in fat (RPKM 20.4), spleen (RPKM 15.6) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the protein Phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin Phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin Phosphatase leads to increased Myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

PPP1R14A Products (2)

mRNA Protein Name
NM_001243947.2 NP_001230876.1 protein phosphatase 1 regulatory subunit 14A isoform 2
NM_033256.3 NP_150281.1 protein phosphatase 1 regulatory subunit 14A isoform 1

PPP1R14A Protein Structure

PP1_inhibitor

PP1_inhibitor: PKC-activated protein phosphatase-1 inhibitor (1 - 134)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 14A

  • 17 kDa PKC-potentiated inhibitory protein of PP1

Recombinant PPP1R14A Proteins

Cat. No. Product Name Accession Purity
HY-P71229 PPP1R14A Protein, Human (His) Q96A00-1 (M1-P147) ≥ 95%, as determined by reducing SDS-PAGE.

PPP1R14A Antibodies

Cat. No. Product Name Application Reactivity
HY-P810768 CPI17 Antibody (YA10011) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Israeli Tick Typhus

  • Israeli Spotted Fever
Japanese Spotted Fever

  • Oriental Spotted Fever

  • Rickettsia Japonica Spotted Fever
Indian Tick Typhus
Melon Allergy

  • Cucumis Melo Fruit Allergy
Epidemic Typhus

  • Typhus

  • Typhus Fever

  • Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii

  • Murine Typhus

  • Classical Typhus

  • Endemic Flea-Borne Typhus

  • Endemic Typhus Fever

  • Epidemic Louse-Borne Typhus

  • Famine Fever

  • Flea-Borne Typhus

  • Jail Fever

  • Louse-Borne Typhus

  • Mexican Typhus

  • Shop Typhus

  • Urban Typhus

  • Brill-Zinsser Disease

  • Endemic Typhus

  • Sylvatic Typhus

  • Epidemic Typhus

  • European Typhus

  • Exanthematic Typhus Fever

  • Exanthematous Typhus

  • Flea Typhus

  • Flea-Borne Rickettsiosis

  • Hospital Fever

  • Louse-Borne [Epidemic] Typhus

  • Louse-Borne Rickettsiosis

  • Moscow Typhus

  • Murine [Endemic] Typhus

  • Petechial Fever

  • Prison Fever

  • Rat Flea Typhus

  • Ship Fever

  • Typhus Exanthematique

  • Typhus, Endemic Flea-Borne

  • Typhus, Epidemic Louse-Borne

  • Typhus Group Rickettsial Disease

  • Relapsing Fever

  • Typhus Fever Nos

  • Typhus Nos

  • Epidemic Typhus Fever

  • Louse-Borne Typhus Fever

  • Classical Typhus Fever

  • Louse-Borne Tabardillo

  • Epidemic Typhus Fever Due To Rickettsia Prowazekii

  • Endemic Murine Typhus

  • Flea-Borne Typhus Fever

  • Murine Endemic Flea Typhus

  • Rat Typhus

  • Typhus Due To Rickettsia Typhi

  • Flea-Borne Tabardillo

  • Rickettsia Typhi Rickettsiosis

  • Mexican Fever

  • Murine Flea-Borne Typhus

  • Mooser Bodies

  • Tsutsugamushi Fever

  • Kedani Fever

  • Mite-Borne Typhus

  • Mite-Borne Typhus Due To Rickettsia Tsutsugamushi

  • Scrub Typhus

  • Tsutsugamushi

  • Tsutsugamushi Disease

  • Scrub Mite-Borne Typhus

  • Sumatran Mite Fever

  • Japanese River Fever

  • Kedani Typhus

  • Rickettsia Tsutsugamushi Rickettsiosis

  • Sumatran Mite Typhus

  • Tropical Typhus

  • Japanese Typhus
Cat-Scratch Disease

  • Cat Scratch Disease

  • Benign Lymphoreticulosis

  • Cat Scratch Fever

  • Debre'S Syndrome

  • Bartonellosis Due To Bartonella Henselae Infection

  • Debre-Mollaret Syndrome

  • Foshay-Mollaret Cat Scratch Fever

  • Oroya Fever

  • Cat-Scratch Fever

  • Benign Inoculation Lymphoreticulosis

  • Catscratch Disease Or Fever

  • Csd - [Cat Scratch Disease]

  • Nonbacterial Regional Lymphadenitis

  • Rochalimaea Henselae Infection
Pediculus Humanus Corporis Infestation

  • Body Louse Infestation

  • Pediculus Corporis

  • Pediculus Humanus Infestation
Ocular Hyperemia

  • Hyperemia Eye

  • Hyperemia Of Conjunctiva
African Tick-Bite Fever

  • Rickettsia Africae Spotted Fever

  • South African Tick-Bite Fever

  • African Tick Bite Fever
Bartonellosis

  • Bartonella Infections

  • Bartonella Infectious Disease

  • Bartonelliasis

  • Rochalimaea Infection

  • Bartonellosis, Unspecified
Rocky Mountain Spotted Fever

  • Brazillian Spotted

  • Choix

  • Exanthematic Typhus Of Sao Paulo

  • Fiebre Maculosa

  • Fiebre Manchada

  • Sao Paulo Typhus

  • So Paulo Fever

  • Tick Typhus

  • Tobia Fever

  • Rmsf

  • Typhus, Tick
Endemic Typhus

  • Murine Typhus

  • Cat Flea Rickettsiosis

  • Fleaborne Typhus

  • Rat-Flea Typhus

  • Rickettsia Felis Spotted Fever

  • Shop Typhus

  • Toulon Typhus

  • Urban Typhus

  • Urban Typhus Of Malaya

  • Flea-Borne Typhus

  • Endemic Flea-Borne Typhus
Ophthalmia Nodosa
Spotted Fever

  • Spotted Fevers

  • Spotted Fever Group Rickettsial Disease

  • Tick-Borne Rickettsioses

  • Tick-Borne Typhus Nos

  • Rocky Mountain Spotted Fever

  • Sao Paulo Fever

  • Sao Paulo Typhus

  • Lone Star Spotted Fever

  • Colombian Spotted Fever

  • American Spotted Fever

  • Tick Typhus Due To Rickettsia Rickettsii

  • Rocky Mountain Tick Fever

  • Boutonneuse Fever

  • Mediterranean Tick Fever

  • Fièvre Boutonneuse

  • Mediterranean Spotted Fever

  • Tick Typhus Due To Rickettsia Conorii

  • African Tick Typhus

  • Indian Tick Typhus

  • Kenya Tick Typhus

  • North Asian Tick Fever

  • Siberian Tick Typhus

  • Tick Typhus Due To Rickettsia Siberica

  • North Asian Spotted Fever

  • Queensland Tick Typhus

  • Queensland Fever
Bacillary Angiomatosis

  • Angiomatosis, Bacillary
Dracunculiasis

  • Guinea Worm Disease

  • Dracontiasis

  • Dracunculosis

  • Infection By Dracunculus Medinensis

  • Gwd

  • Guinea Worm Infection

  • Parasitic Infection Caused By Dracunculus Medinensis

  • Medina Worm Disease

  • Medinensis

  • Medina Worm Infestation

  • Dracunculus Medinensis Infestation

  • Guinea Worm Infestation
Boutonneuse Fever

  • Mediterranean Spotted Fever

  • African Tick Typhus

  • Boutonneuse Disease

  • Conor And Bruch'S Disease

  • Kenya Fever

  • Kenya Tick Typhus

  • Kenyan Tick Typhus

  • Marseilles Fever

  • Mediterranean Tick Fever

  • Rickettsia Conorii Spotted Fever

  • South African Tick-Bite Fever

  • African Tick Bite Fever
Cholinergic Urticaria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10983 PPP1R14A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19291 Ppp1r14a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25781 Ppp1r14a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PPP1R14A VGNC VGNC:53753
Mus musculus PPP1R14A MGD MGI:1931139
Rattus norvegicus PPP1R14A RGD RGD:620536
Macaca mulatta PPP1R14A VGNC VGNC:76255
Bos taurus PPP1R14A VGNC VGNC:33226
Others PPP1R14A NCBI