PPP1R14A Protein, Human (His)
The PPP1R14A protein is a key cellular regulator that effectively inhibits PPP1CA and exhibits significant activity amplification upon phosphorylation. This phosphorylation-induced transformation turns PPP1R14A into a dynamic molecular switch adept at regulating PPP1CA substrate phosphorylation. PPP1R14A Protein, Human (His) is the recombinant human-derived PPP1R14A protein, expressed by E. coli , with C-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The PPP1R14A protein is a key cellular regulator that effectively inhibits PPP1CA and exhibits significant activity amplification upon phosphorylation. This phosphorylation-induced transformation turns PPP1R14A into a dynamic molecular switch adept at regulating PPP1CA substrate phosphorylation. PPP1R14A Protein, Human (His) is the recombinant human-derived PPP1R14A protein, expressed by E. coli , with C-6*His labeled tag.
Background
PPP1R14A, a pivotal player in cellular regulation, serves as a potent inhibitor of PPP1CA. Its inhibitory prowess takes center stage, showcasing over a thousand-fold increase in activity when phosphorylated. This phosphorylation-induced augmentation transforms PPP1R14A into a molecular switch, a dynamic regulator adept at modulating the phosphorylation status of PPP1CA substrates. In the intricate dance of cellular signaling, PPP1R14A emerges as a key orchestrator, particularly influential in the realm of smooth muscle contraction. This multifaceted role positions PPP1R14A as a critical element in the intricate machinery governing cellular processes and adds a layer of nuanced control to the dynamic landscape of cellular signaling.
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
Q96A00-1 (M1-P147)
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Molecular Construction
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N-term
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PPP1R14A (M1-P147)
Accession # Q96A00-1 -
6*His
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C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
PPP1R14A; PKC-Potentiated Inhibitory Protein Of PP1; Prev. PPP1INL; CPI17; CPI-17; Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A; Protein Kinase C-Potentiated Inhibitor Protein Of 17 KDa; 17-KDa PKC-Potentiated Inhibitory Protein Of PP1; 17 KD
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AA Sequence
MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP
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Predicted Molecular Mass
17.8 kDa
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Molecular Weight
Approximately 23-26 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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