PPP1R14A Protein, Human (His)

The PPP1R14A protein is a key cellular regulator that effectively inhibits PPP1CA and exhibits significant activity amplification upon phosphorylation. This phosphorylation-induced transformation turns PPP1R14A into a dynamic molecular switch adept at regulating PPP1CA substrate phosphorylation. PPP1R14A Protein, Human (His) is the recombinant human-derived PPP1R14A protein, expressed by E. coli , with C-6*His labeled tag. The total length of PPP1R14A Protein, Human (His) is 147 a.a., with molecular weight of 23-26 kDa.

PPP1R14A, a pivotal player in cellular regulation, serves as a potent inhibitor of PPP1CA. Its inhibitory prowess takes center stage, showcasing over a thousand-fold increase in activity when phosphorylated. This phosphorylation-induced augmentation transforms PPP1R14A into a molecular switch, a dynamic regulator adept at modulating the phosphorylation status of PPP1CA substrates. In the intricate dance of cellular signaling, PPP1R14A emerges as a key orchestrator, particularly influential in the realm of smooth muscle contraction. This multifaceted role positions PPP1R14A as a critical element in the intricate machinery governing cellular processes and adds a layer of nuanced control to the dynamic landscape of cellular signaling.

Human

E. coli

C-6*His

Q96A00 (M1-P147)

94274  [NCBI]

MAAQRLGKRVLSKLQSPSRARGPGGSPGGLQKRHARVTVKYDRRELQRRLDVEKWIDGRLEELYRGMEADMPDEINIDELLELESEEERSRKIQGLLKSCGKPVEDFIQELLAKLQGLHRQPGLRQPSPSHDGSLSPLQDRARTAHP

23-26 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.