PPP1R14A - protein phosphatase 1 regulatory inhibitor subunit 14A Gene

Homo sapiens

Also known as CPI17; CPI-17; PPP1INL

Gene ID: 94274 | Gene type: protein coding

About PPP1R14A

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,251,237-38,256,374 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues and 3 paralogues. Broad expression in fat (RPKM 20.4), spleen (RPKM 15.6) and 20 other tissues.

Summary

The protein encoded by this gene belongs to the protein Phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin Phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin Phosphatase leads to increased Myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

PPP1R14A Products(2)

mRNA	Protein	Name
NM_001243947.2	NP_001230876.1	protein phosphatase 1 regulatory subunit 14A isoform 2
NM_033256.3	NP_150281.1	protein phosphatase 1 regulatory subunit 14A isoform 1

PPP1R14A Protein Structure

PP1_inhibitor

0
100
147 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 14A

17 kDa PKC-potentiated inhibitory protein of PP1

Recombinant PPP1R14A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71229	PPP1R14A Protein, Human (His)	Q96A00 (M1-P147)	≥95%

Related Diseases

Diseases

Alias

Israeli Tick Typhus

Israeli Spotted Fever

Japanese Spotted Fever

Oriental Spotted Fever

Rickettsia Japonica Spotted Fever

Indian Tick Typhus

Melon Allergy

Cucumis Melo Fruit Allergy

Epidemic Typhus

Typhus	Typhus Fever
Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii	Murine Typhus
Classical Typhus	Endemic Flea-Borne Typhus
Endemic Typhus Fever	Epidemic Louse-Borne Typhus
Famine Fever	Flea-Borne Typhus
Jail Fever	Louse-Borne Typhus
Mexican Typhus	Shop Typhus
Urban Typhus	Brill-Zinsser Disease
Endemic Typhus	Sylvatic Typhus
Epidemic Typhus	European Typhus
Exanthematic Typhus Fever	Exanthematous Typhus
Flea Typhus	Flea-Borne Rickettsiosis
Hospital Fever	Louse-Borne [Epidemic] Typhus
Louse-Borne Rickettsiosis	Moscow Typhus
Murine [Endemic] Typhus	Petechial Fever
Prison Fever	Rat Flea Typhus
Ship Fever	Typhus Exanthematique
Typhus, Endemic Flea-Borne	Typhus, Epidemic Louse-Borne
Typhus Group Rickettsial Disease	Relapsing Fever
Typhus Fever Nos	Typhus Nos
Epidemic Typhus Fever	Louse-Borne Typhus Fever
Classical Typhus Fever	Louse-Borne Tabardillo
Epidemic Typhus Fever Due To Rickettsia Prowazekii	Endemic Murine Typhus
Flea-Borne Typhus Fever	Murine Endemic Flea Typhus
Rat Typhus	Typhus Due To Rickettsia Typhi
Flea-Borne Tabardillo	Rickettsia Typhi Rickettsiosis
Mexican Fever	Murine Flea-Borne Typhus
Mooser Bodies	Tsutsugamushi Fever
Kedani Fever	Mite-Borne Typhus
Mite-Borne Typhus Due To Rickettsia Tsutsugamushi	Scrub Typhus
Tsutsugamushi	Tsutsugamushi Disease
Scrub Mite-Borne Typhus	Sumatran Mite Fever
Japanese River Fever	Kedani Typhus
Rickettsia Tsutsugamushi Rickettsiosis	Sumatran Mite Typhus
Tropical Typhus	Japanese Typhus

Cat-Scratch Disease

Cat Scratch Disease	Benign Lymphoreticulosis
Cat Scratch Fever	Debre'S Syndrome
Bartonellosis Due To Bartonella Henselae Infection	Debre-Mollaret Syndrome
Foshay-Mollaret Cat Scratch Fever	Oroya Fever
Cat-Scratch Fever	Benign Inoculation Lymphoreticulosis
Catscratch Disease Or Fever	Csd - [Cat Scratch Disease]
Nonbacterial Regional Lymphadenitis	Rochalimaea Henselae Infection

Pediculus Humanus Corporis Infestation

Body Louse Infestation	Pediculus Corporis
Pediculus Humanus Infestation

Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva

African Tick-Bite Fever

Rickettsia Africae Spotted Fever	South African Tick-Bite Fever
African Tick Bite Fever

Bartonellosis

Bartonella Infections	Bartonella Infectious Disease
Bartonelliasis	Rochalimaea Infection
Bartonellosis, Unspecified

Rocky Mountain Spotted Fever

Brazillian Spotted	Choix
Exanthematic Typhus Of Sao Paulo	Fiebre Maculosa
Fiebre Manchada	Sao Paulo Typhus
So Paulo Fever	Tick Typhus
Tobia Fever	Rmsf
Typhus, Tick

Endemic Typhus

Murine Typhus	Cat Flea Rickettsiosis
Fleaborne Typhus	Rat-Flea Typhus
Rickettsia Felis Spotted Fever	Shop Typhus
Toulon Typhus	Urban Typhus
Urban Typhus Of Malaya	Flea-Borne Typhus
Endemic Flea-Borne Typhus

Ophthalmia Nodosa

Spotted Fever

Spotted Fevers	Spotted Fever Group Rickettsial Disease
Tick-Borne Rickettsioses	Tick-Borne Typhus Nos
Rocky Mountain Spotted Fever	Sao Paulo Fever
Sao Paulo Typhus	Lone Star Spotted Fever
Colombian Spotted Fever	American Spotted Fever
Tick Typhus Due To Rickettsia Rickettsii	Rocky Mountain Tick Fever
Boutonneuse Fever	Mediterranean Tick Fever
Fièvre Boutonneuse	Mediterranean Spotted Fever
Tick Typhus Due To Rickettsia Conorii	African Tick Typhus
Indian Tick Typhus	Kenya Tick Typhus
North Asian Tick Fever	Siberian Tick Typhus
Tick Typhus Due To Rickettsia Siberica	North Asian Spotted Fever
Queensland Tick Typhus	Queensland Fever

Bacillary Angiomatosis

Angiomatosis, Bacillary

Dracunculiasis

Guinea Worm Disease	Dracontiasis
Dracunculosis	Infection By Dracunculus Medinensis
Gwd	Guinea Worm Infection
Parasitic Infection Caused By Dracunculus Medinensis	Medina Worm Disease
Medinensis	Medina Worm Infestation
Dracunculus Medinensis Infestation	Guinea Worm Infestation

Boutonneuse Fever

Mediterranean Spotted Fever	African Tick Typhus
Boutonneuse Disease	Conor And Bruch'S Disease
Kenya Fever	Kenya Tick Typhus
Kenyan Tick Typhus	Marseilles Fever
Mediterranean Tick Fever	Rickettsia Conorii Spotted Fever
South African Tick-Bite Fever	African Tick Bite Fever

Cholinergic Urticaria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10983	PPP1R14A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PPP1R14A	VGNC	VGNC:53753
Mus musculus	PPP1R14A	MGD	MGI:1931139
Rattus norvegicus	PPP1R14A	RGD	RGD:620536
Macaca mulatta	PPP1R14A	VGNC	VGNC:76255
Bos taurus	PPP1R14A	VGNC	VGNC:33226
Others	PPP1R14A	NCBI

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