Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum

  • J Nat Prod. 2006 Mar;69(3):394-6. doi: 10.1021/np050144x.
Mira M Konopleva  1 ,  Irena Matławska ,  Małgorzata Wojcińska ,  Ahmed A Ahmed ,  Maria Rybczyńska ,  Anna Paszel ,  Shinji Ohta ,  Toshifumi Hirata ,  Wiesława Bylka ,  Tom J Mabry ,  John F Cannon
Affiliations
  • 1. Department of Pharmacognosy and Botany, Vitebsk State University, Republic of Belarus.
PMID: 16562842 DOI: 10.1021/np050144x
Abstract

A new diterpene glucoside (1), named sylviside, was isolated from the aerial parts of Gnaphalium sylvaticum. Its structure was elucidated as 2beta,15alpha,20alpha-trihydroxy-19,20-dicarboxy-ent-kaur-16-ene 2beta-O-(2'-angelate)-beta-D-glucopyranoside, on the basis of spectroscopic analysis ((1)H NMR, (13)C NMR, HMQC, HMBC, NOESY), and was confirmed by X-ray crystallographic analysis. Sylviside (1) displayed weak cytotoxicity against HeLa WT (human epitheloid cervical carcinoma) cells and was also evaluated for its effects on reversing multidrug resistance in HeLa cells overexpressing MDR1.