YKL-06-062
Based on 2 publication(s) in Google Scholar
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 2172617-16-0
- Formula: C31H39N7O
- Molecular Weight:525.69
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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Kinase Inhibitor Library
HY-L009
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Targeted Diversity Library
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Kinase Inhibitor Library Mini
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MCE Bioactive Compound Library
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Publications Citing Use of MedChemExpress (MCE) YKL-06-062
More
Biological Activity
YKL 06-062 (0.0004-16 μM; 3 hours) increases MITF mRNA expression in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human melanocyte cells, UACC62 melanoma cells
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Concentration:0.0004 μM, 0.004 μM, 0.04 μM, 0.4 μM, 4 μM,8 μM,16 μM
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Incubation Time:3 hours
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Result:Unregulated MITF mRNA expression.
Chemical Information
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CAS No. 2172617-16-0
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Appearance Solid
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Molecular Weight 525.69
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Formula C31H39N7O
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Color Light yellow to yellow
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SMILES
O=C1N(C2CCCCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3CN1C6=C(C)C=CC=C6C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Br J Pharmacol
Dual pharmacological targeting of coactivator-associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice. [Abstract]2026 Apr 29. PMID: 42055601 -
Mediators Inflamm
Inhibition of SIK1 Alleviates the Pathologies of Psoriasis by Disrupting IL-17 Signaling. [Abstract]2025 Feb 7:2025:3540219. PMID: 39959414
Solvent & Solubility
DMSO : 25 mg/mL (47.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9023 mL | 9.5113 mL | 19.0226 mL | 47.5565 mL |
| 5 mM | 0.3805 mL | 1.9023 mL | 3.8045 mL | 9.5113 mL | |
| 10 mM | 0.1902 mL | 0.9511 mL | 1.9023 mL | 4.7557 mL | |
| 15 mM | 0.1268 mL | 0.6341 mL | 1.2682 mL | 3.1704 mL | |
| 20 mM | 0.0951 mL | 0.4756 mL | 0.9511 mL | 2.3778 mL | |
| 25 mM | 0.0761 mL | 0.3805 mL | 0.7609 mL | 1.9023 mL | |
| 30 mM | 0.0634 mL | 0.3170 mL | 0.6341 mL | 1.5852 mL | |
| 40 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1889 mL |
YKL-06-062 Related Classifications
HY-129141 Related Classifications
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