DL5050
DL5050 is a selective and potent human constitutive androstane receptor (hCAR) agonist that does not activate pregnane X receptor (PXR). DL5050 preferentially induces the expression of CYP2B6 (target of hCAR) over CYP3A4 (target of hPXR) on both the mRNA and protein levels. DL5050 can be used for the researches of cancer and metabolic disease, such as diabetes.
For research use only. We do not sell to patients.
- CAS No.: 2259710-64-8
- Formula: C23H15Cl2N3O2
- Molecular Weight:436.29
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
0.37 μM
Compound: 19; DL5050
|
Agonist activity at human CAR transfected in human HepG2 cells cotransfected with CYP2B6 incubated for 23 hrs by luciferase reported gene assay
Agonist activity at human CAR transfected in human HepG2 cells cotransfected with CYP2B6 incubated for 23 hrs by luciferase reported gene assay
|
[PMID: 31312405] |
| HepG2 | EC50 |
5.9 μM
Compound: 19; DL5050
|
Agonist activity at human PXR transfected in human HepG2 cells cotransfected with CYP3A4 incubated for 23 hrs by luciferase reporter gene assay
Agonist activity at human PXR transfected in human HepG2 cells cotransfected with CYP3A4 incubated for 23 hrs by luciferase reporter gene assay
|
[PMID: 31312405] |
Chemical Information
-
CAS No. 2259710-64-8
-
Molecular Weight 436.29
-
Formula C23H15Cl2N3O2
-
SMILES
ClC1=CC=C(CO/N=C/C2=C(C3=CC=C4C=CC=CC4=C3)N=C5OC=CN52)C=C1Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz