2. Metabolic Enzyme/Protease
  3. Liposome
  4. DMPG

DMPG  (Synonyms: L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol)

Cat. No.: HY-177191
Handling Instructions Technical Support

DMPG (L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol) is a phospholipid that can be used for preparing formulations such as liposomes or gels. DMPG can be used in the research of drug delivery.

For research use only. We do not sell to patients.

DMPG

DMPG Chemical Structure

CAS No. : 185463-22-3

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DMPG Related Antibodies

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Description

DMPG (L-α-Dimyristoylphosphatidylglycerol; 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol) is a phospholipid that can be used for preparing formulations such as liposomes or gels. DMPG can be used in the research of drug delivery[1][2].

In Vitro

DMPG has been shown
to present a large gel-fluid transition region, ranging from 18 to 35 ℃[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DMPG Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-t MRT0-t
Mice[1] 20 mg/kg i.p. 1.87 ± 0.28 h 0.73 ± 0.34 h 261.9 ± 146.2 ng/mL 188.5 ± 119.3 ng·h/mL 1.65 ± 0.37 h
In Vivo

DMPG (1.6-4.8 mg/kg; i.v.; single dose) exhibits formulation-dependent elimination kinetics, with longer half-lives (4.6-8.1 h) when administered as part of an amphotericin B phospholipid complex suspension versus 1.1-2.3 h when administered alone, and shows dose-proportional increases in Cmax and AUC0-t across all tested doses, with preferential tissue accumulation in lungs, liver, spleen, and kidneys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Crl:CD(SD) rats (225 ± 25 g, equal gender distribution, SPF grade)[1]
Dosage: 1.6 mg/kg, 3.2 mg/kg, 4.8 mg/kg
Administration: i.v.; single dose
Result: Exhibited elimination half-life values of 1.081 ± 0.277 h (1.6 mg/kg), 1.448 ± 0.287 h (3.2 mg/kg), 2.348 ± 0.325 h (4.8 mg/kg) when administered alone.
Showed maximum plasma concentration (Cmax) values of 10168.9 ± 2262.1 μg/L (1.6 mg/kg), 14904.4 ± 1706.4 μg/L (3.2 mg/kg), 78723.6 ± 56402.7 μg/L (4.8 mg/kg) when administered alone.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC0-∞) values of 3586.7 ± 721.7 μg/L·h (1.6 mg/kg), 4913.1 ± 632.8 μg/L·h (3.2 mg/kg), 23248.4 ± 15236.8 μg/L·h (4.8 mg/kg) when administered alone.
Exhibited elimination half-life values of 8.078 ± 6.523 h (1.6 mg/kg), 4.561 ± 3.542 h (3.2 mg/kg), 4.645 ± 3.531 h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Showed maximum plasma concentration (Cmax) values of 3922.9 ± 2039.2 μg/L (1.6 mg/kg), 8201.2 ± 2227.9 μg/L (3.2 mg/kg), 10523.3 ± 2049.1 μg/L (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC0-∞) values of 1568.3 ± 695.5 μg/L·h (1.6 mg/kg), 3198.9 ± 695.5 μg/L·h (3.2 mg/kg), 5096.1 ± 1166.1 μg/L·h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Rapidly distributed to most tissues, with highest concentrations in lungs, liver, spleen, and kidneys; minimal levels detected in brain, heart, small intestine, muscle, testes, ovaries, uterus, adipose tissue, and stomach.
Molecular Weight

666.86

Formula

C34H67O10P
CAS No.
SMILES

OCC(O)COP(OC[C@@H](COC(CCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCC)=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DMPG Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMPG185463-22-3L-α-Dimyristoylphosphatidylglycerol 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerolLiposomegelliverratsamphotericin B phospholipidInhibitorinhibitorinhibit

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