DMPG

Crl:CD(SD) rats (225 ± 25 g, equal gender distribution, SPF grade)^[1]

1.6 mg/kg, 3.2 mg/kg, 4.8 mg/kg

i.v.; single dose

Exhibited elimination half-life values of 1.081 ± 0.277 h (1.6 mg/kg), 1.448 ± 0.287 h (3.2 mg/kg), 2.348 ± 0.325 h (4.8 mg/kg) when administered alone.
Showed maximum plasma concentration (Cmax) values of 10168.9 ± 2262.1 μg/L (1.6 mg/kg), 14904.4 ± 1706.4 μg/L (3.2 mg/kg), 78723.6 ± 56402.7 μg/L (4.8 mg/kg) when administered alone.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC_0-∞) values of 3586.7 ± 721.7 μg/L·h (1.6 mg/kg), 4913.1 ± 632.8 μg/L·h (3.2 mg/kg), 23248.4 ± 15236.8 μg/L·h (4.8 mg/kg) when administered alone.
Exhibited elimination half-life values of 8.078 ± 6.523 h (1.6 mg/kg), 4.561 ± 3.542 h (3.2 mg/kg), 4.645 ± 3.531 h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Showed maximum plasma concentration (Cmax) values of 3922.9 ± 2039.2 μg/L (1.6 mg/kg), 8201.2 ± 2227.9 μg/L (3.2 mg/kg), 10523.3 ± 2049.1 μg/L (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Demonstrated area under the concentration-time curve from 0 to infinity (AUC_0-∞) values of 1568.3 ± 695.5 μg/L·h (1.6 mg/kg), 3198.9 ± 695.5 μg/L·h (3.2 mg/kg), 5096.1 ± 1166.1 μg/L·h (4.8 mg/kg) when administered as part of amphotericin B phospholipid complex suspension.
Rapidly distributed to most tissues, with highest concentrations in lungs, liver, spleen, and kidneys; minimal levels detected in brain, heart, small intestine, muscle, testes, ovaries, uterus, adipose tissue, and stomach.