2. GPCR/G Protein
  3. GLP Receptor
  4. ECC-5004

ECC-5004 (Compound 1) is a GLP-1 receptor agonist with an EC50 of 0-20 nM. ECC-5004 exhibits strong inhibitory effects on OATP1B1, with an IC50 < 1 μM. ECC-5004 can be used to study diseases such as diabetes, obesity, and non-alcoholic fatty liver disease.

For research use only. We do not sell to patients.

ECC-5004

ECC-5004 Chemical Structure

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ECC-5004 Related Antibodies

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Description

ECC-5004 (Compound 1) is a GLP-1 receptor agonist with an EC50 of 0-20 nM. ECC-5004 exhibits strong inhibitory effects on OATP1B1, with an IC50 < 1 μM. ECC-5004 can be used to study diseases such as diabetes, obesity, and non-alcoholic fatty liver disease[1].

Parmacokinetics
Species Dose Route Cmax AUC F
Rat 10 mg/kg p.o. 571 ng/mL 4528 ng·h/mL 10 %
Clinical Trial
Molecular Weight

882.96

Formula

C48H48F2N10O5
SMILES

CC1=CC(N2N=C3CCN([C@H](C3=C2N4C=CN(C4=O)C5=C(C6=C(N(N=C6)C)C=C5)F)C)C(C7=C(N8C=CC([C@H]9CCOC(C)(C9)C)=CC8=C7)[C@]%10(C[C@@H]%10C)C%11=NOC(N%11)=O)=O)=CC(C)=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ECC-5004 Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ECC-5004ECC5004ECC 5004GLP ReceptorGLP-1 receptor agoniststype 2 diabetesmetabolic diseasesnon-alcoholic steatohepatitis (NASH)pharmacokinetic profileInhibitorinhibitorinhibit

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