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ERD03 

Cat. No.: HY-139059
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ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a Kd of 17±7 μM . ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder disease research.

For research use only. We do not sell to patients.

ERD03 Chemical Structure

ERD03 Chemical Structure

CAS No. : 1377897-01-2

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Description

ERD03 is a potent disruptor of the EXOSC3-RNA interaction, with a Kd of 17±7 μM . ERD03 induces PCH1B-like phenotype in zebrafish embryo and can be used for neurological disorder disease research[1].

IC50 & Target

Kd: 17±7 μM (EXOSC3-RNA interaction)[1]

In Vitro

ERD03 inhibits the binding of  G-rich RNA and EXOSC3 with ~18% inhibition at 50 μM[1].
ERD03 (50 μM; 5 days) causes significant spinal curvature and recapitulates PCH1B phenotype in development in zebrafish embryos[1].
ERD03 (50 μM) induces a ~6-fold upregulation of ataxin1b mRNA and results in a minor accumulation of ataxin1a mRNA in embryos. ERD03 induces an atrophy of the zebrafish cerebellum and results in zebrafish cerebella half the size of control brains in DMSO[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

339.43

Formula

C₂₁H₂₅NO₃

CAS No.
SMILES

O=C(N1CC2=C(C=CC=C2)C(O)C1)C3=CC=CC(CCC(C)(O)C)=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ERD03ERD 03ERD-03OthersEXOSC3-RNAneurological disorderPCH1BPontocerebellar Hypoplasia type 1BInhibitorinhibitorinhibit

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ERD03
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