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Cat. No.: HY-187125

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11β-HSD1-IN-27

11β-HSD1-IN-27 is a human and mouse 11β-hydroxysteroid dehydrogenase type I inhibitor. 11β-HSD1-IN-27 inhibits catalytic activity of target enzymes in cell-based assays. 11β-HSD1-IN-27 exhibits moderate stability in mouse and human liver microsomes.

For research use only. We do not sell to patients.

CAS No.: 946400-19-7
Formula: C₁₉H₁₆ClF₄N₃O₂S
Molecular Weight:461.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

11β-HSD1-IN-27 Chemical Structure

CAS No.: 946400-19-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target^[1]

11β-HSD1

In Vitro

11β-HSD1-IN-27 (compound 19) potently inhibits human 11β-HSD1 in stable CHO cells expressing the enzyme, with an IC₅₀ of 0.016 μM^[1].
11β-HSD1-IN-27 potently inhibits mouse 11β-HSD1 in stable CHO cells expressing the enzyme, with an IC₅₀ of 0.010 μM^[1].
11β-HSD1-IN-27 (11-point dilutions; 30 min compound incubation, 120 min total) inhibits mouse 11β-HSD1 in stable CHO cells expressing the enzyme in the presence of 10% human serum, with an IC₅₀ of 0.398 μM^[1].
11β-HSD1-IN-27 (1 μM; up to 30 min) has a metabolic half-life of 13 min in mouse liver microsomes^[1].
11β-HSD1-IN-27 (1 μM; up to 30 min) has a metabolic half-life of 14 min in human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 946400-19-7
Molecular Weight 461.86
Formula C₁₉H₁₆ClF₄N₃O₂S
SMILES

FC(F)(C1=C(C=CC(F)=C1)N2C[C@H](N(CC2)S(=O)(C3=C(C=C(C=C3)C#N)Cl)=O)C)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wan ZK, et al. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. Journal of medicinal chemistry. 2009 Sep 10;52(17):5449-61. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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