Cetrorelix-d10
Cetrorelix-d10 (SB-75-d10) is deuterium labeled Cetrorelix. Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice.
For research use only. We do not sell to patients.
- Formula: C70H82D10ClN17O14
- Molecular Weight:1441.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 120287-85-6
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Molecular Weight 1441.10
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Formula C70H82D10ClN17O14
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SMILES
OC1=CC=C(C[C@@H](C(N[C@@H](C(N[C@]([2H])(C(N[C@H](C(N2[C@H](C(N[C@@H](C(N)=O)C)=O)CCC2)=O)CCCNC(N)=N)=O)C([2H])(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[2H])=O)CCCNC(N)=O)=O)NC([C@@H](NC([C@@H](CC3=CN=CC=C3)NC([C@@H](CC4=CC=C(Cl)C=C4)NC([C@@H](CC5=CC6=C(C=C5)C=CC=C6)NC(C)=O)=O)=O)=O)CO)=O)C=C1
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Synonyms
SB-75-d10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9(5):788-91. [Content Brief]
[3]. Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19(6):1294-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cetrorelix-d10 Related Classifications
HY-P0009S1 Related Classifications
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