SLAMF8 - SLAM family member 8 Gene

Also Known as BLAME; CD353; SBBI42

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56833

About SLAMF8

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,826,873-159,837,492 (from NCBI)

This gene has 4 transcripts (splice variants), 102 orthologues and 9 paralogues. Broad expression in appendix (RPKM 13.5), lymph node (RPKM 12.8) and 22 other tissues.

Summary

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]

SLAMF8 Products (2)

mRNA Protein Name
NM_001330741.2 NP_001317670.1 SLAM family member 8 isoform 2
NM_020125.3 NP_064510.1 SLAM family member 8 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SLAM family member 8

  • B lymphocyte activator macrophage expressed

SLAMF8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLAMF8 Q9P0V8 GPD1L Homo sapiens Q8N335
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLAMF8 Proteins

Cat. No. Product Name Accession Purity
HY-P71318 SLAMF8 Protein, Human (HEK293, His) Q9P0V8-1 (A23-D233) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78925 SLAMF8 Protein, Human (Biotinylated, HEK293, His-Avi) Q9P0V8-1 (A23-D233) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Familial Cold Autoinflammatory Syndrome 3

  • Plaid

  • Familial Atypical Cold Urticaria

  • Facu

  • FCAS3

  • Antibody Deficiency And Immune Dysregulation, Plcg2-Associated

  • Plcg2-Associated Antibody Deficiency And Immune Dysregulation

  • Familial Cold Urticaria With Common Variable Immunodeficiency

  • Plcg2 Associated Antibody Deficiency And Immune Dysregulation

  • Antibody Deficiency And Immune Dysregulation Placg2-Associated

  • Autoinflammatory Syndrome, Cold, Familial, Type 3
Brachydactyly, Type C

  • Brachydactyly Type C

  • BDC

  • Brachydactyly Haws Type

  • Brachydactyly, Haws Type

  • Brachydactyly C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12982 SLAMF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18716 Slamf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25203 Slamf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLAMF8 VGNC VGNC:53130
Rattus norvegicus SLAMF8 RGD RGD:1306263
Felis catus SLAMF8 VGNC VGNC:65178
Mus musculus SLAMF8 MGD MGI:1921998
Macaca mulatta SLAMF8 VGNC VGNC:77545
Bos taurus SLAMF8 VGNC VGNC:34656
Others SLAMF8 NCBI