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slamf8-protein-human-biotinylated-hek293-his-avi

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  • HY-P700672
    CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi)

    slamf3; CD229; LY9; AI893573; Lgp100; T100

    		 Human HEK293
    CD229/SLAMF3 Protein, a self-ligand receptor in the SLAM family, modulates immune cell activation and differentiation through cell interactions. Crucial for innate and adaptive immune responses, its activities are controlled by SH2D1A/SAP and/or SH2D1B/EAT-2. It mediates T-cell adhesion, promotes Th17 differentiation with IL-17 secretion requiring SH2D1A, and facilitates RORC recruitment to the IL-17 promoter. CD229/SLAMF3 acts as a negative immune regulator, inhibiting autoantibody responses and CD4(+) T-cell IFN-gamma secretion. It regulates thymic innate CD8(+) T-cell size and iNKT cell development, interacting with SH2D1A, SH2D1B, INPP5D, and PTPN11, blocking PTPN11 interaction with SH2D1A. CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD229/SLAMF3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) is 407 a.a., with molecular weight of 70-80 kDa.
  • HY-P72413
    CD150/SLAMF1 Protein, Human (Biotinylated, HEK293, His-Avi)

    Signaling Lymphocytic Activation Molecule; CDw150; IPO-3; CD150; slamf1; SLAM

    		 Human HEK293
    CD150/SLAMF1 Protein, a self-ligand receptor in the SLAM family, modulates immune cell activation and differentiation, influencing both innate and adaptive immune responses. Its activities depend on cytoplasmic adapters SH2D1A/SAP and/or SH2D1B/EAT-2. CD150 induces distinct signaling in T-lymphocytes and B-cells, involving SH2D1A (and possibly SH2D1B) and PTPN11. It drives IL-2-independent T-cell proliferation, IFN-gamma production, and downstream signaling pathways. CD150 is crucial for T follicular helper cell differentiation, allergic response regulation, and macrophage innate immune responses against Gram-negative bacteria. It also serves as a receptor for Measles virus, isoform 4 included. CD150/SLAMF1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD150/SLAMF1 protein, expressed by HEK293, with C-Avi, C-6*His labeled tag. The total length of CD150/SLAMF1 Protein, Human (Biotinylated, HEK293, His-Avi) is 217 a.a., with molecular weight of 45-65 kDa.
  • HY-P72416
    CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His-Avi)

    CD2 Subset 1; CRACC; Membrane protein FOAP-12; Novel Ly9; protein 19A; CD319; CS1

    		 Human HEK293
    The FITC-labeled CRACC/SLAMF7 protein, a self-ligand receptor in the SLAM family, intricately regulates immune cell activation and differentiation through finely tuned interactions. Isoform 1 mediates NK cell activation via a SH2D1A-independent ERK-mediated pathway, positively regulating NK cell functions dependent on phosphorylated SH2D1B. It inhibits NK cell function in the absence of SH2D1B and acts as an inhibitory factor in T-cells. In LPS-activated monocytes, it negatively regulates pro-inflammatory cytokine production. However, isoform 3 shows no NK cell activation, suggesting isoform-specific immune modulation. CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CRACC/SLAMF7 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of CRACC/SLAMF7 Protein, Human (Biotinylated, HEK293, His-Avi) is 204 a.a., with molecular weight of 35-55 kDa.
  • HY-P72414
    CD84/SLAMF5 Protein, Human (Biotinylated, HEK293, His-Avi)

    SLAM family member 5; Cell surface antigen MAX.3; Hly9-beta; Signaling lymphocytic activation molecule 5; CD84

    		 Human HEK293
    The CD84/SLAMF5 protein, a self-ligand receptor in the SLAM family, modulates diverse immune cell activities through homo- or heterotypic cell-cell interactions. It finely tunes its functions based on the presence or absence of small cytoplasmic adapter proteins, including SH2D1A/SAP and/or SH2D1B/EAT-2. CD84/SLAMF5 mediates NK cell cytotoxicity dependent on SH2D1A and SH2D1B, enhances T-cell proliferative responses, and amplifies IFNG secretion. It is crucial for prolonged T-cell:B-cell contact, germinal center formation, and maintaining B-cell tolerance. In mast cells, it negatively regulates immunoglobulin epsilon receptor signaling, and in macrophages, it positively regulates LPS-induced MAPK phosphorylation and NF-kappaB activation. Additionally, CD84/SLAMF5 positively regulates macroautophagy in dendritic cells and forms homodimers, interacting with CD48 molecules and various signaling proteins, including SH2D1A/SAP, SH2D1B/EAT-2, PTPN6/SHP-1, PTPN11/SHP-2, and INPP5D/SHIP1. CD84/SLAMF5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD84/SLAMF5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of CD84/SLAMF5 Protein, Human (Biotinylated, HEK293, His-Avi) is 199 a.a., with molecular weight of 40-50 kDa.

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