Im-m7GDP sodium
Based on 1 Customer Validation
Im-m7GDP sodium is a capping reagent and also the P-imidazolide of N7-methylguanosine 5'-diphosphate. Im-m7GDP sodium introduces an m7G cap structure to the monophosphate group of branched oligoribonucleotides, and is used in nucleic acid synthesis-related research.
For research use only. We do not sell to patients.
- Purity: 89.15%
- CAS No.: 240137-51-3
- Formula: C14H18N7NaO10P2
- Molecular Weight:529.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Im-m7GDP (10 mM; 3 h) sodium efficiently introduces an m7G cap structure to the 5′ phosphorylated branched strand of synthetic oligoribonucleotides under the specified reaction conditions[2].
Im-m7GDP (10 mM; 3 h) sodium effectively introduces a cap structure onto 5′-monophosphorylated 68-nt chemically synthesized RNA in a cell-free in vitro reaction[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 240137-51-3
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Appearance Solid
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Molecular Weight 529.27
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Formula C14H18N7NaO10P2
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Color White to off-white
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SMILES
O=C1C([N+](C)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(N4C=CN=C4)(O[Na])=O)=O)O3)=C2NC(N)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (188.94 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Geng J, et al. Cap-related modifications of RNA regulate binding to IFIT proteins. RNA (New York, N.Y.). 2024 Sep 16;30(10):1292-1305. [Content Brief]
[2]. Fukuchi K, et al. Internal cap-initiated translation for efficient protein production from circular mRNA. Nature biotechnology. 2026 Jan;44(1):120-132. [Content Brief]
[3]. Ohashi S, et al. Selection of Short 5'-UTR of Chemically Synthesized mRNA to Improve Translation Efficiency. Chemical & pharmaceutical bulletin. 2025;73(5):449-456. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8894 mL | 9.4470 mL | 18.8939 mL | 47.2349 mL |
| 5 mM | 0.3779 mL | 1.8894 mL | 3.7788 mL | 9.4470 mL | |
| 10 mM | 0.1889 mL | 0.9447 mL | 1.8894 mL | 4.7235 mL | |
| 15 mM | 0.1260 mL | 0.6298 mL | 1.2596 mL | 3.1490 mL | |
| 20 mM | 0.0945 mL | 0.4723 mL | 0.9447 mL | 2.3617 mL | |
| 25 mM | 0.0756 mL | 0.3779 mL | 0.7558 mL | 1.8894 mL | |
| 30 mM | 0.0630 mL | 0.3149 mL | 0.6298 mL | 1.5745 mL | |
| 40 mM | 0.0472 mL | 0.2362 mL | 0.4723 mL | 1.1809 mL | |
| 50 mM | 0.0378 mL | 0.1889 mL | 0.3779 mL | 0.9447 mL | |
| 60 mM | 0.0315 mL | 0.1574 mL | 0.3149 mL | 0.7872 mL | |
| 80 mM | 0.0236 mL | 0.1181 mL | 0.2362 mL | 0.5904 mL | |
| 100 mM | 0.0189 mL | 0.0945 mL | 0.1889 mL | 0.4723 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Im-m7GDP sodium Related Classifications
HY-178674A Related Classifications
Powered by Bioz
- Im-m7GDP
- 240137-51-3
- Biochemical Assay Reagents
- Nucleoside Antimetabolite/Analog
- m7G cap structure
- C57BL6N mice
- HiBiT peptide
- branched oligoribonucleotides
- chemically synthesized mRNA
- synthetic oligoribonucleotides
- chemically synthesized RNA
- Balb/c mice
- N7-methylguanosine 5′-diphosphate
- trinucleotide cap analogs
- Inhibitor
- inhibitor
- inhibit