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Referencia número: HY-P11864

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DOTA-SMIC-1014

DOTA-SMIC-1014 is a DOTA chelator-conjugated precursor of the c-Met-targeting peptide SMIC-1014 (HY-P11863). DOTA-SMIC-1014 binds to the extracellular domain of c-Met (K_d = 42.83 nM). After radiolabeling to [⁶⁸Ga]Ga-SMIC-1014, DOTA-SMIC-1014 acts as a positron emission tomography (PET) probe that achieves specific tumor uptake in xenografts and functions as a diagnostic probe targeting c-Met. SMIC-1014 can be used in research related to colon cancer, hepatocellular carcinoma, and prostate cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₆₈H₁₀₆N₂₀O₂₃
Peso molecular:1571.69

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Please store the product under the recommended conditions in the Certificate of Analysis.

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DOTA-SMIC-1014 Chemical Structure

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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs) :

In Vitro

[⁶⁸Ga]Ga-SMIC-1014 binds to c-Met on HCT-116 human colon cancer cells, with a K_d value of 42.83 nM and a B_maxvalue of 188291 CPM, indicating high binding affinity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DOTA-SMIC-1014 (800-fold molar excess; i.v.; single coinjection with [⁶⁸Ga]Ga-SMIC-1014) significantly blocks specific c-Met-targeted tumor uptake of [⁶⁸Ga]Ga-SMIC-1014 in HCT-116 xenografts mice, reducing uptake by ~66% at 30 minutes post-injection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude (female, 8-10 weeks old, subcutaneous HCT-116 cell injection model)^[1]
Dosage:

800-fold molar excess
Administration:

i.v.; single coinjection with [⁶⁸Ga]Ga-SMIC-1014
Result:

Reduced tumor uptake of [⁶⁸Ga]Ga-SMIC-1014 to 1.22 %ID/g at 30 min post-injection.
Reduced tumor uptake of [⁶⁸Ga]Ga-SMIC-1014 to 0.93 %ID/g at 60 min post-injection.
Reduced tumor uptake of [⁶⁸Ga]Ga-SMIC-1014 to 1.08 %ID/g in the 30-minute biodistribution study.
Decreased tumor uptake by ~66% at 30 minutes post-injection.

Chemical Information

Peso molecular 1571.69
Fòrmula C₆₈H₁₀₆N₂₀O₂₃
Sequence

DOTA-{βAla}-d{Arg-Leu-Asp}-Gly-d{Pro-Glu}-Gly-d{Pro-Phe-Gln}-NH2
Sequence Shortening

DOTA-{βAla}-d{RLD}-G-d{PE}-G-d{PFQ}-NH2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Luo R, et al. Harnessing Insights of Hepatocyte Growth Factor Kringle 3 Domain to Develop c-Met Targeted Positron Emission Tomography Probe. Journal of medicinal chemistry. 2026 Jan 08;69(1):488-500. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DOTA-SMIC-1014

Ver todos los productos específicos de isoformas Radionuclide-Drug Conjugates (RDCs)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

DOTA-SMIC-1014 Related Classifications

HY-P11864 Related Classifications