SMIC-1014 

SMIC-1014 is a cellular mesenchymal-epithelial transition factor (c-Met) ligand. ^[1] SMIC-1014 binds to the c-Met ectodomain without activating c-Met phosphorylation or inducing receptor internalization. ^[1] SMIC-1014, when radiolabeled as [⁶⁸Ga]Ga-SMIC-1014, acts as a positron emission tomography (PET) probe with defined pharmacokinetics, achieves specific tumor uptake in xenografts, and functions as a c-Met-targeted diagnostic probe. ^[2] SMIC-1014 can be used for the research of colon cancer, hepatocellular carcinoma, prostate cancer^[1].

SMIC-1014 (10^-3 to 10^-10 M; 60 min) competes with [⁶⁸Ga]Ga-SMIC-1014 for binding to c-Met on HCT-116 cells, with an IC₅₀ of 116.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1185.29

C₅₂H₈₀N₁₆O₁₆

{βAla}-d{Arg-Leu-Asp}-Gly-d{Pro-Glu}-Gly-d{Pro-Phe-Gln}-NH2

{βAla}-d{RLD}-G-d{PE}-G-d{PFQ}-NH2

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luo R, et al.. Harnessing Insights of Hepatocyte Growth Factor Kringle 3 Domain to Develop c-Met Targeted Positron Emission Tomography Probe. Journal of medicinal chemistry. 2026 Jan 08;69(1):488-500.