Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27
- Arch Pharm Res. 2011 Jun;34(6):901-5. doi: 10.1007/s12272-011-0606-1.
Affiliations
- 1. Beijing Key Laboratory of Plant Resource Research and Development, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100048, China. [email protected]
PMID: 21725810
DOI: 10.1007/s12272-011-0606-1
Abstract
A new cell cycle inhibitor, nidurufin (1), was isolated from the marine-derived fungus Penicillium flavidorsum SHK1-27. An evaluation of antitumor activity indicated that 1 induced in vitro cell cycle arrest at G(2)/M transition in the K562 cell line in a concentration and time dependent manner, with an IC(50) value of 12.6 M.