856925-75-2
856925-75-2
Chemical Structure
S-(-)-7-Desmethyl-8-nitro blebbistatin
- CAS No.: 856925-75-2
- Formula:C17H13N3O4
- Molecular Weight:323.30
IUPAC Name: (S)-3a-hydroxy-7-nitro-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
InChIKey: VIMYHNYWFMRDKQ-QGZVFWFLSA-N
SMILES: O=C1[C@@]2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=CC([N+]([O-])=O)=C4
Biological Activity: S-(-)-7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor[1][2].
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S-(-)-7-Desmethyl-8-nitro blebbistatin | S-(-)-7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-)-Blebbistatin (HY-13441). (-)-Blebbistatin is a selective non-muscle myosin II inhibitor. | |||||||||||||||||||||
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References
- [1]. Cristina Lucas-Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)-Blebbistatin. Chemistry Europe, 2005, 9: 1736-1740.
- [2]. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4816-27. [Content Brief]
