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Cat. No.: HY-P12011

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MTS peptide

MTS peptide is a short peptide with a mitochondria-targeting sequence. In F-M-LNP, MTS peptide is displayed on the particle surface via thiol-maleimide conjugation, and is specifically responsible for being recognized by the mitochondrial proteins TOMM20/22, "anchoring" the nanoparticles to the outer mitochondrial membrane, followed by membrane potential-independent bilayer membrane penetration mediated by fluorinated lipids. MTS peptide can be used in the research of Leber's hereditary optic neuropathy.

For research use only. We do not sell to patients.

Formula: C₇₃H₁₂₁N₂₁O₁₇S₂
Molecular Weight:1629.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MTS peptide Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

MTS peptide modification enhances the mitochondrial targeting selectivity of 6F-LNPs in N2a cells by increasing interactions with TOMM20 and TOMM22, resulting in a Pearson's colocalization coefficient of 0.90 between delivered pDNA and mitochondria^[1].
MTS peptide-modified 6F-M-LNPs (2 μg/mL; 24 h followed by 48 h fresh medium culture) deliver functional hND4 to GM10742 LHON patient cells, restoring mitochondrial function with a 5-fold increase in hND4 protein expression and significant improvements in MMP, ATP production, and oxygen consumption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1629.00
Formula C₇₃H₁₂₁N₂₁O₁₇S₂
SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Sequence

Met-Leu-Ser-Leu-Arg-Gln-Ser-Ile-Arg-Phe-Phe-Lys-Cys
Sequence Shortening

MLSLRQSIRFFKC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Mitochondria-targeted gene delivery using fluorinated lipid nanoparticles to alleviate Leber's hereditary optic neuropathy. Nature communications. 2025 Dec 04;16(1):10891. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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