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Cat. No.: HY-144623

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Antiviral agent 15

Antiviral agent 15 (Compound 15f) is a Clofazimine derivative with antiviral effects. Antiviral agent 15 inhibits both rabies virus and pseudo-typed SARS-CoV-2 with EC₅₀ values of 1.45 μM and 14.6 μM, respectively.

For research use only. We do not sell to patients.

Formula: C₂₇H₂₄FN₅O
Molecular Weight:453.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antiviral agent 15 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Antiviral agent 15 (Compound 15f) affects the rabies and SARS-CoV-2 proliferation by targeting G or S protein to block the viral membrane fusion, as well as binding to L protein or nsp13 to inhibit viral biosynthesis, respectively, and thus synergistically exerted antiviral effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Kunming mice, Antiviral agent 15 (Compound 15f) is given orally in a single-dosing experiment at 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg and 800 mg/kg, respectively. The mice are closely monitored for 7 days, and all the surviving mice had glossy hair, fleshy body and good appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 453.51
Formula C₂₇H₂₄FN₅O
SMILES

COC1=CC=C(N=C1)N2C3=CC=CC=C3N=C4C=C(/C(C=C42)=N/C(C)C)NC5=CC(F)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xintong Zhang, et al. Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism. Eur J Med Chem. 2022 Apr 15;234:114209. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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