Spint1 - serine protease inhibitor, Kunitz type 1 Gene

Also Known as HAI-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20732

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within extracellular matrix organization; neural tube closure; and placenta development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1). [provided by Alliance of Genome Resources, Apr 2022]

Spint1 Products (3)

mRNA Protein Name
NM_001412660.1 NP_001399589.1 kunitz-type protease inhibitor 1 precursor
NM_001412661.1 NP_001399590.1 kunitz-type protease inhibitor 1 precursor
NM_016907.3 NP_058603.2 kunitz-type protease inhibitor 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: Inferred from mutant phenotype
17174946 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
15964823 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
17174946 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
19592578 MGI
acts upstream of or within placenta blood vessel development IMP
IMP: Inferred from mutant phenotype
17174946 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25758223 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kunitz-type protease inhibitor 1

  • hepatocyte growth factor activator inhibitor type 1

Recombinant Spint1 Proteins

Cat. No. Product Name Accession Purity
HY-P73092 HAI-1 Protein, Mouse (HEK293, Fc) Q9R097 (E30-E443) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13685 SPINT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18570 Spint1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25054 Spint1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spint1 NCBI NCBI:6692