SPINT1 - serine peptidase inhibitor, Kunitz type 1 Gene

Also Known as HAI; HAI1; MANSC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6692

About SPINT1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,844,048-40,858,207 (from NCBI)

This gene has 11 transcripts (splice variants), 530 orthologues and 13 paralogues. Broad expression in placenta (RPKM 87.0), duodenum (RPKM 69.0) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the Kunitz family of serine Protease Inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SPINT1 Products (6)

mRNA Protein Name
NM_001032367.2 NP_001027539.1 kunitz-type protease inhibitor 1 isoform 2 precursor
NM_001386873.1 NP_001373802.1 kunitz-type protease inhibitor 1 isoform 1 precursor
NM_001386874.1 NP_001373803.1 kunitz-type protease inhibitor 1 isoform 3 precursor
NM_001386875.1 NP_001373804.1 kunitz-type protease inhibitor 1 isoform 4 precursor
NM_003710.4 NP_003701.1 kunitz-type protease inhibitor 1 isoform 2 precursor
NM_181642.3 NP_857593.1 kunitz-type protease inhibitor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15713485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPINT1 Protein Structure

MANEC

MANEC: MANEC domain (47 - 140)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (250 - 301)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (334 - 369)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (391 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
Protein Preferred Names Protein Names

kunitz-type protease inhibitor 1

  • HAI-1

SPINT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPINT1 O43278 HGFAC Homo sapiens Q04756
X-Ray Diffraction
15713485
Intra
SPINT1 O43278 HGFAC Homo sapiens Q04756
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPINT1 Proteins

Cat. No. Product Name Accession Purity
HY-P73091 HAI-1 Protein, Human (HEK293, His) O43278-2 (G36-V433) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pulmonary Embolism And Infarction
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Ichthyosis, Congenital, Autosomal Recessive 11

  • Autosomal Recessive Congenital Ichthyosis 11

  • Ichthyosis With Hypotrichosis, Autosomal Recessive

  • Arih

  • Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis

  • Autosomal Recessive Ichthyosis With Hypotrichosis

  • ARCI11

  • Ifah

  • Hypotrichosis-Congenital Ichthyosis Syndrome

  • Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome

  • Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome

  • Ichthyosis-Hypotrichosis Syndrome

  • Ifah Syndrome

  • Ihs
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13685 SPINT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18570 Spint1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25054 Spint1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPINT1 RGD RGD:1303138
Felis catus SPINT1 VGNC VGNC:65640
Canis familiaris SPINT1 VGNC VGNC:46746
Bos taurus SPINT1 VGNC VGNC:35221
Mus musculus SPINT1 MGD MGI:1338033
Others SPINT1 NCBI