CD1B - CD1b molecule Gene

Also Known as R1; CD1; CD1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 910

About CD1B

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,285,405-158,331,531 (from NCBI)

This gene has 2 transcripts (splice variants), 459 orthologues and 22 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]

CD1B Products (1)

mRNA	Protein	Name
NM_001764.3	NP_001755.1	T-cell surface glycoprotein CD1b precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12118248	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD1B Protein Structure

C1-set

0
100
200
300
333 a.a.

Protein Preferred Names	Protein Names
T-cell surface glycoprotein CD1b	CD1B antigen, b polypeptide

CD1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD1B	P29016	B2M	Homo sapiens	P61769	X-Ray Diffraction	14764708
Intra	CD1B	P29016	B2M	Homo sapiens	P61769	Anti Tag CoIP	33961781
Intra	CD1B	P29016	B2M	Homo sapiens	P61769	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75438	CD1B Protein, Human (HEK293, Fc)	P29016 (S18-S303)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Follicular Dendritic Cell Sarcoma	Dendritic Cell Sarcoma Dendritic Cell Sarcoma, Follicular Follicular Dendritic Cell Tumour Dendritic Cell Sarcoma, Interdigitating Dendritic Cell Sarcoma, Not Otherwise Specified
Non-Langerhans-Cell Histiocytosis	Histiocytosis, Non-Langerhans-Cell Non-Langerhans Cell Histiocytosis
Interdigitating Dendritic Cell Sarcoma	Interdigitating Cell Sarcoma Dendritic Cell Sarcoma, Interdigitating Reticulum Cell Sarcoma
Adult Xanthogranuloma
Rhinoscleroma
Langerhans Cell Sarcoma	Malignant Langerhans Cell Sarcoma
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Reticulohistiocytic Granuloma	Reticulohistiocytoma Solitary Reticulohistiocytoma Solitary Histiocytoma Solitary Reticulohistiocytosis
Juvenile Xanthogranuloma	Multiple Eruptive Juvenile Xanthogranuloma Naevoxanthoendothelioma Xanthoma Neviforme Xanthogranuloma, Juvenile
Multicentric Reticulohistiocytosis	Lipoid Dermatoarthritis Giant Cell Histiocytomatosis
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Orbital Cancer	Malignant Neoplasm Of Orbit Orbital Tumor Orbital Neoplasms Neoplasm Of Orbit Proper Orbit Cancer Primary Malignant Neoplasm Of Orbit Intraorbital Cancer
Erdheim-Chester Disease	Ecd Erdheim Chester Disease Lipoid Granulomatosis Lipid Granulomatosis Polyostotic Sclerosing Histiocytosis
Granuloma Annulare	Granulome Annulare Ga - [Granuloma Annulare]
Fibrosarcoma Of Bone	Malignant Histiocytosis Malignant Fibroxanthoma Malignant Fibrous Histiocytoma Histiocytic Medullary Reticulosis Nasal Type Extranodal Nk/T-Cell Lymphoma Histiocytic Sarcoma
Cobblestone Retinal Degeneration	Paving Stone Retinal Degeneration Paving Stone Degeneration Of Retina
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Granulomatous Dermatitis
Tuberculoid Leprosy	Smooth Leprosy Type T Leprosy Leprosy Tuberculoid Leprosy, Tuberculoid
Histiocytosis-Lymphadenopathy Plus Syndrome	H Syndrome Histiocytosis With Joint Contractures And Sensorineural Deafness Faisalabad Histiocytosis Shml Hjcd Rosai-Dorfman Disease Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus Phid Sinus Histiocytosis And Massive Lymphadenopathy Familial Rosai-Dorfman Disease Slc29a3 Spectrum Disorder Sinus Histiocytosis With Massive Lymphadenopathy Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Rosai-Dorfman Disease, Familial Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness Rdd Rosaï-Dorfman Disease Slc29a3 Disorder Destombes-Rosai-Dorfman Disease Rosai-Dorfman-Destombes Disease HLAS Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness H Disease Sinus Histiocytosis
Spongiotic Dermatitis
Polyclonal Hypergammaglobulinemia	Polyclonal Gammopathy
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Mixed Type Thymoma	Thymoma, Mixed Type Thymoma, Type Ab
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
Exophthalmos	Proptosis
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Orbital Disease	Orbit Orbital Diseases
Mixed Phenotype Acute Leukemia, T/Myeloid	Doid:0081039
Necrobiosis Lipoidica	Oppenheim-Urbach Disease Necrobiosis Lipoidica Diabeticorum
Seborrheic Dermatitis	Seborrhoeic Dermatitis Seborrhea Seborrhoeic Eczema Skin Seborrheic Dermatitis, Seborrheic
Histiocytic Sarcoma	Malignant Histiocytosis
Central Diabetes Insipidus	Neurogenic Diabetes Insipidus Diabetes Insipidus Cranial Type Diabetes Insipidus Neurogenic Diabetes Insipidus Neurohypophyseal Neurohypophyseal Diabetes Insipidus Pituitary Diabetes Insipidus Cdi Doid:0081055 Diabetes Insipidus Di - [Diabetes Insipidus] Adh - [Antidiuretic Hormone Secretion] Deficiency Diabetes Mellitus Insipidus Familial Diabetes Insipidus Antidiuretic Hormone Hyposecretion Vasopressin Deficiency Syndrome Primary Central Diabetes Insipidus Vasopressin Deficiency Vasopressin Hyposecretion Diabetes Insipidus Secondary To Vasopressin Deficiency
Lichen Nitidus	Pinkus' Disease
Kimura Disease	Kimura'S Disease Eosinophilic Lymphogranuloma Eosinophilic Granuloma Of Soft Tissue Eosinophilic Hyperplastic Lymphogranuloma Eosinophilic Lymphofollicular Granuloma Eosinophilic Lymphofolliculosis
Dendritic Cell Thymoma	Epithelioid Thymoma Type B Thymoma
Otorrhea	Discharging Ear
Epithelial Malignant Thymoma	Squamoid Thymoma Thymoma, Epithelial Well Differentiated Thymic Carcinoma Thymoma, Type B3
Large Cell Acanthoma
Interstitial Pneumonitis, Desquamative, Familial	Desquamative Interstitial Pneumonia DIP Pneumonitis, Desquamative Interstitial, Familial Pneumonia, Desquamative Interstitial, Familial Interstitial Lung Disease, Desquamative Ild, Desquamative Familial Desquamative Interstitial Pneumonitis Rbild Respiratory Bronchiolitis-Associated Interstitial Lung Disease Respiratory Bronchiolitis Associated Interstitial Lung Disease
Keratosis, Seborrheic	Seborrheic Keratosis Keratosis, Seborrheic, Somatic Basal Cell Papilloma Keratosis Seborrheica KERSEB
Frontal Sinus Benign Neoplasm	Neoplasm Of Frontal Sinus Tumor Of The Frontal Sinus
Lichen Disease
Chronic Laryngitis
Cortical Thymoma	Polygonal Cell Thymoma Thymoma, Cortical Thymoma, Type B2
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Geographic Tongue	Benign Migratory Glossitis Glossitis Areata Exfoliativa Glossitis, Benign Migratory Pityriasis Linguae Ectopic Geographic Tongue Erythema Migrans Erythema Chronicum Migrans Benign Migrating Glossitis Geographical Tongue Lingua Geographica Erythema Migrans Of Tongue Wandering Rash Of Tongue
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Beach Ear	Acute Swimmer'S Ear Acute Bacterial Inflammation Of External Ear Acute Otitis Externa, Diffuse Acute Swimmers' Ear Tank Ear
Acanthoma
Mite Infestation	Mite Infestations Acariasis Infestation By Mites Nos
Folliculitis
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Balloon Cell Malignant Melanoma
Vulvar Proximal-Type Epithelioid Sarcoma
Central Epithelioid Sarcoma	Proximal-Type Epithelioid Sarcoma
Diencephalic Astrocytoma	Astrocytoma Of Diencephalon
T-Cell Prolymphocytic Leukemia	T Cell Prolymphocytic Leukemia Prolymphocytic Leukemia, T-Cell Type T-Pll T-Cell Chronic Lymphocytic Leukemia Lymphocytic Leukemia T-Cell Chronic Doid:0081042 Leukemia, T-Cell, Chronic Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Thymus Gland Disease	Disease Of Thymus Gland
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer
Nodular Tenosynovitis	Synovioma, Benign Benign Synovioma Benign Tumor Of Synovium Localized Giant Cell Tumor Of Tenosynovium Giant Cell Tumor Of Tendon Sheath
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144012A	DPPE-PEG350	Antagonist	99%	Unkown
HY-RS02200	CD1B Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-157193	Diacylglyceride	Chemical	/	Unkown