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Referencia número: HY-176131

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AMX5160

AMX5160 (36) is an orally active BTK inhibitor, with an IC₅₀ of 0.98 nM against mutant BTK^C481S. AMX5160 (36) can be used in the research for leukemia, lymphoma, multiple sclerosis, and other autoimmune diseases.

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No. CAS: 2639293-95-9
Fòrmula: C₂₈H₂₇ClN₄O₃
Peso molecular:502.99

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

AMX5160 Chemical Structure

No. CAS: 2639293-95-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

AMX5160 possesses IC₅₀ values of 93.2 nM and 85.85 nM in TMD8 and Ba/F3-BTK-C481S cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	Plasma Concentration	AUC	T_1/2	Clearance (CL)	V_d	T_max	Bioavailability
Mice^[1]	1 mg/kg	i.v.	2090±229 ng/mL	4229±742 ng·h/mL	3.55±0.17 h	4.01±0.76 mL/min/kg	0.66 L/kg	/	/
Mice^[1]	10 mg/kg	p.o.	1580±427 ng/mL	14146±5297 ng·h/mL	2.51±0.06 h	/	/	2 h	33.4%

In Vivo

AMX5160 (36; NIH/3T3-FL-BTK-C481S xenograft BALB/c nude mouse; 10, 25, 75 mg/kg; PO; bid) significantly inhibits tumor growth in a dose dependent manner. The tumor growth inhibition (TGI) is 58%, 63%, and 82% at doses of 10, 25, and 75 mg/kg, respectively. AMX5160 (36) was well tolerated in mice at higher doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2639293-95-9
Peso molecular 502.99
Fòrmula C₂₈H₂₇ClN₄O₃
SMILES

ClC1=CC(OC2=CC=CC=C2)=CC=C1C(C3=CNC4=NC=CC(N[C@H](CC5)CC[C@H]5NC(C)=O)=C34)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Debasis Das, et al. Discovery of Reversible, Noncovalent Bruton’s Tyrosine Kinase Inhibitors Targeting BTK C481S Mutation. ACS Med. Chem. Lett. 2025.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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