Antimicrobial agent-34

Antimicrobial agent-34 can be stably present in human serum, plasma and blood, with MBCs of 16, 16 and 32 μg/mL, respectively, without losing its antimicrobial effect^[1].
Antimicrobial agent-34 has the strongest antibacterial activity against 6 Gram-positive bacteria, with a wide antibacterial spectrum and a MIC range of 1-4 μg/mL. It also has good antibacterial activity against Klebsiella pneumoniae ATCC10031, Unstable Bacteria ATCC19606, and Escherichia coli ATCC25922, with MICs of 4, 2, and 4 μg/mL, respectively^[1].
Antimicrobial agent-34 (1×-16× MIC) shows rapid antibacterial activity against Staphylococcus aureus, and it is dose-dependent^[1].
Antimicrobial agent-34 (2-16 mg/mL; 0-24 h) is difficult to induce resistance. The resistance test of Staphylococcus aureus ATCC43300 under sub-MIC (1/2 MIC) shows a MIC change of only 2-4 times^[1].
Antimicrobial agent-34 (2-64 mg/mL, 0-20 days) has a strong ability to inhibit biofilm formation and destroy pre-formed biofilm, and it is dose-dependent^[1].
Antimicrobial agent-34 (2-32 mg/mL, 0-20 min) disruptes the transmembrane potential of S. aureus, thereby increasing permeability and effectively increasing the levels of ROS, DNA, and protein in S. aureus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.