Ascrinvacumab
Based on 2 publication(s) in Google Scholar
Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC).
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- Pureza: 97.45%
- No. CAS: 1463459-96-2
- Peso molecular:144.08 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ascrinvacumab
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Actividad biológica
Human IgG2 kappa
Human
ACVRL1/ALK-1
Ascrinvacumab binds to cellular human ALK1 with a Kd value of 7 nm[1]. Ascrinvacumab (30 min) blocks bone morphogenetic protein 9 (BMP9)- and fetal calf serum (FCS)-induced responses and mitigates BMP9-induced intensity and duration of Smad1 phosphorylation[1]. Ascrinvacumab (0.01-10 μg/mL; 2 h) inhibits BMP9 binding to ALK1[1]. Ascrinvacumab (40 μg/mL; 2 h) potently inhibits endothelial sprouting in human umbilical vein endothelial cells (HUVECs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG2 kappa
ELISA, FACS, Functional assay
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Immobilized Human ALK-1 Protein (His Tag) can bind Ascrinvacumab. The EC50 for this effect is 1.84 ng/mL.
Chemical Information
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No. CAS 1463459-96-2
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Appearance Liquid
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Peso molecular 144.08 kDa
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Color Colorless to light yellow
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SMILES
[Ascrinvacumab]
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Synonyms
Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962; GT-90001C
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cardiovasc Res
Smad1/5 is acetylated in the dorsal aortae of the mouse embryo before the onset of blood flow, driving early arterial gene expression. [Abstract]2024 Sep 10:cvae201. PMID: 39253943 -
FASEB J
SCUBE3 promotes osteogenic differentiation and mitophagy in human bone marrow mesenchymal stem cells through the BMP2/TGF-β signaling pathway. [Abstract]2024 Sep;38(17):e70011. PMID: 39250278
Pureza y Documentación
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Ficha de datos (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ascrinvacumab Related Classifications
HY-P99353 Related Classifications
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