Brigatinib C
Based on 1 Customer Validation
Brigatinib C is a prodrug of ALK inhibitor, which can be used to syntheis PROTACs.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.72%
- No. CAS: 1197958-75-0
- Fòrmula: C28H37ClN7O2P
- Peso molecular:570.07
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Actividad biológica
|
EGFR |
FAK |
PYK2 |
PTK6 |
|
Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SR | IC50 |
6.8 nM
Compound: Brigatinib C
|
Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
|
[PMID: 34138566] |
| SR | IC50 |
6.8 nM
Compound: 3
|
Antiproliferative activity against human SR cells assessed as reduction in cell growth
Antiproliferative activity against human SR cells assessed as reduction in cell growth
|
[PMID: 32179332] |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1197958-75-0
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Appearance Solid
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Peso molecular 570.07
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Fòrmula C28H37ClN7O2P
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Color Off-white to light brown
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SMILES
COC1=CC(N2CCC(CC2)N3CCNCC3)=CC=C1NC4=NC=C(C(NC5=CC=CC=C5P(C)(C)=O)=N4)Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (266 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)