GRIN2D - glutamate ionotropic receptor NMDA type subunit 2D Gene

Also Known as EB11; NR2D; DEE46; EIEE46; GluN2D; NMDAR2D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2906

About GRIN2D

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,393,668-48,444,931 (from NCBI)

This gene has 1 transcript (splice variant), 280 orthologues, 17 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA Receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

GRIN2D Products (1)

mRNA	Protein	Name
NM_000836.4	NP_000827.2	glutamate receptor ionotropic, NMDA 2D precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	26919761	GOA
enables glutamate-gated calcium ion channel activity	IDA IDA: Inferred from direct assay	26875626	GOA
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	27616483	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11937501	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in calcium ion transmembrane import into cytosol	IDA IDA: Inferred from direct assay	26875626	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	26875626	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26875626	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIN2D Protein Structure

ANF_receptor

SBP_bac_3

Lig_chan

0
300
600
900
1200
1336 a.a.

Protein Preferred Names	Protein Names
glutamate receptor ionotropic, NMDA 2D	N-methyl D-aspartate receptor subtype 2D

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 46	DEE46 Epileptic Encephalopathy, Early Infantile, 46 Eiee46 Developmental And Epileptic Encephalopathy, 46 Early Infantile Epileptic Encephalopathy 46
Non-Specific Early-Onset Epileptic Encephalopathy	Undetermined Early-Onset Epileptic Encephalopathy Non-Specific Eoee Undetermined Eoee
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
High Pressure Neurological Syndrome
Autosomal Dominant Intellectual Developmental Disorder 6	Autosomal Dominant Non-Syndromic Intellectual Disability 6 Autosomal Dominant Mental Retardation 6 Mrd6 Mental Retardation, Autosomal Dominant, Type 6 Mental Retardation, Autosomal Dominant 6
Schizophrenia 7	SCZD7 Schizophrenia Susceptibility Locus, Chromosome 13q-Related Schizophrenia 7 With Or Without An Affective Disorder
Retinitis Pigmentosa 30	RP30 Retinitis Pigmentosa-30 Retinitis Pigmentosa, Type 30
Landau-Kleffner Syndrome	Acquired Epileptic Aphasia Lks Acquired Aphasia With Convulsive Disorder Acquired Epileptiform Aphasia Landau Kleffner Syndrome Childhood Epileptic Aphasia
Benign Familial Neonatal Epilepsy	Familial Neonatal Seizures Bfns Benign Familial Neonatal Convulsions Benign Familial Neonatal Seizures Epilepsy Benign Neonatal Familial Familial Benign Neonatal Convulsions Benign Neonatal Familial Convulsions Familial Benign Neonatal Epilepsy Epilepsy, Benign Neonatal, 2 Benign Familial Convulsion
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS05805	GRIN2D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GRIN2D	VGNC	VGNC:41495
Mus musculus	GRIN2D	MGD	MGI:95823
Rattus norvegicus	GRIN2D	RGD	RGD:2740
Bos taurus	GRIN2D	VGNC	VGNC:29649
Others	GRIN2D	NCBI