Rps6kb1 - ribosomal protein S6 kinase, polypeptide 1 Gene

Also Known as S6K; S6K1; p70s6k; P70S6K1; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72508

About Rps6kb1

Chromosome 11: 86,389,697-86,435,631 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 155 orthologues, 7 paralogues and is associated with 25 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 5.), limb E14.5 (RPKM 4.8) and 26 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including cellular response to interferon-gamma; long-chain fatty acid import into cell; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including behavioral fear response; cellular response to hormone stimulus; and protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb1 Products (3)

mRNA Protein Name
NM_001363162.1 NP_001350091.1 ribosomal protein S6 kinase beta-1 isoform 3
NM_028259.4 NP_082535.1 ribosomal protein S6 kinase beta-1 isoform 2
NM_001114334.2 NP_001107806.1 ribosomal protein S6 kinase beta-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
20657550 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
15249583 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
15249583 MGI
Biological Process GO Annotation Evidence Referencias Source
acts upstream of or within behavioral fear response IGI
IGI: Inferred from genetic interaction
24990923 MGI
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
17556672 MGI
acts upstream of or within cellular response to insulin stimulus IGI
IGI: Inferred from genetic interaction
24349514 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
24990923 MGI
involved in cellular response to type II interferon IMP
IMP: Inferred from mutant phenotype
28178239 MGI
acts upstream of or within germ cell development IDA
IDA: Inferred from direct assay
12140361 MGI
involved in long-chain fatty acid import into cell IMP
IMP: Inferred from mutant phenotype
28178239 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
18174371 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
18174371 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11493700 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11493700 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15249583 MGI
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
28178239 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15249583 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15249583 MGI
Cellular Component GO Annotation Evidence Referencias Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18174371 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18174371 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11493700 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6kb1 Protein Structure

STKc_p70S6K

STKc_p70S6K: cd05584 (93 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase beta-1

  • 70 kDa ribosomal protein S6 kinase 1

  • p70 S6 kinase alpha

  • p70 ribosomal S6 kinase alpha

  • ribosomal protein S6 kinase I

  • ribosomal protein S6 kinase, 70kD, polypeptide 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-RS12262 RPS6KB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12263 Rps6kb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12264 Rps6kb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6kb1 NCBI NCBI:6198