NAPSA - napsin A aspartic peptidase Gene

Also Known as KAP; Kdap; NAP1; NAPA; SNAPA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9476

About NAPSA

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,358,477-50,365,639 (from NCBI)

This gene has 7 transcripts (splice variants), 119 orthologues and 9 paralogues. Restricted expression toward lung (RPKM 393.9).

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

NAPSA Products (1)

mRNA	Protein	Name
NM_004851.3	NP_004842.1	napsin-A preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	14766755	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	18216060	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in membrane protein proteolysis	IDA IDA: Inferred from direct assay	14766755	GOA
involved in surfactant homeostasis	IDA IDA: Inferred from direct assay	18216060	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in alveolar lamellar body	IDA IDA: Inferred from direct assay	18216060	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	18216060	GOA
located in lysosome	IDA IDA: Inferred from direct assay	14766755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPSA Protein Structure

Asp

0
100
200
300
400
420 a.a.

Protein Preferred Names	Protein Names
napsin-A	ASP4

NAPSA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	NAPSA	O96009	LCE1B	Homo sapiens	Q5T7P3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

NAPSA Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P81885	Napsin A Antibody (YA1630)	WB, IHC-P, IP	Human
HY-P83883	Napsin A Antibody (YA3580)	WB, IHC-P, ELISA	Human, Rat
HY-P83883A	Napsin A Antibody (YA3580)(PBS only)	WB, IHC-P, ELISA	Human, Rat
HY-P85849	Napsin A Antibody (YA5541)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P86021	Napsin A Antibody (YA5713)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Ovarian Clear Cell Adenofibroma
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Endometrial Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of Endometrium
Solid Adenocarcinoma With Mucin Production
Cervical Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Cervix Uteri
Cervical Endometrioid Adenocarcinoma	Endometrioid Carcinoma Of The Cervix Uteri
Ureter Squamous Cell Carcinoma	Ureteral Epidermoid Carcinoma
Pleomorphic Carcinoma
Krukenberg Carcinoma	Krukenberg Tumor Krukenberg Neoplasm Krukenberg'S Tumor
Bladder Clear Cell Adenocarcinoma	Bladder Mesonephric Adenocarcinoma Clear Cell Adenocarcinoma Of Bladder
Lung Giant Cell Carcinoma	Carcinoma, Giant Cell Giant Cell Carcinoma Giant Cell Lung Carcinoma Carcinoma Giant Cell Giant Cell Carcinoma Of Lung
Clear Cell Adenofibroma	Cystadenofibroma
Papillary Adenoma	Glandular Papilloma Adenoma
Lung Combined Type Small Cell Carcinoma	Combined Small Cell Carcinoma Of The Lung Combined Type Small Cell Carcinoma Of Lung
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Non-Invasive Bladder Urothelial Carcinoma	Stage 0 Bladder Urothelial Carcinoma
Large Cell Neuroendocrine Carcinoma
Papillary Adenofibroma
Bronchus Adenoma	Bronchial Adenoma Adenoma Of The Bronchus
Lung Sarcomatoid Carcinoma	Sarcomatoid Carcinoma Of The Lung Pulmonary Sarcomatoid Carcinoma
Bladder Adenocarcinoma	Adenocarcinoma Of Bladder Adenocarcinoma Of The Urinary Bladder Bladder Adenocarcinoma, Not Otherwise Specified Adenocarcinoma Bladder
Cervical Mucinous Adenocarcinoma
Mucinous Adenocarcinoma	Mucin-Producing Adenocarcinoma Mucin-Secreting Adenocarcinoma Mucin-Secreting Carcinoma Mucous Carcinoma Pseudomyxoma Peritonei With Unknown Primary Site Adenocarcinoma, Mucinous
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Mucinous Lung Adenocarcinoma
Trigonitis	Bladder Trigonitis Pseudomembranous Trigonitis
Ovarian Endodermal Sinus Tumor	Endodermal Sinus Tumor Of Ovary Ovarian Yolk Sac Tumor Endodermal Sinus Tumour Of Ovary Ovarian Endodermal Sinus Tumour Ovarian Yolk Sac Tumour
Respiratory System Benign Neoplasm
Bronchial Benign Neoplasm	Bronchus Neoplasm Neoplasm Of Bronchus Bronchial Neoplasms Bronchial Neoplasm
Adenofibroma
Adenocarcinoma In Situ
Lung Clear Cell Carcinoma
Parotid Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Parotid Gland
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Ovarian Primitive Germ Cell Tumor
Basaloid Squamous Cell Carcinoma	Basaloid Carcinoma
Clear Cell Adenocarcinoma	Mesonephroma Water-Clear Cell Adenocarcinoma Adenocarcinoma, Clear Cell Malignant Mesonephroma Mesonephroid Clear Cell Carcinoma Mesonephroma, Malignant Water-Clear Cell Carcinoma Wolffian Duct Neoplasm Adenocarcinoma Clear Cell Mesonephric Tumor
Keratinizing Squamous Cell Carcinoma	Squamous Cell Carcinoma, Keratinizing Keratinizing Epidermoid Carcinoma
Papillary Adenocarcinoma	Infiltrating And Papillary Adenocarcinoma Infiltrating Papillary Adenocarcinoma Adenocarcinoma Papillary Adenocarcinoma, Papillary
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Esophageal Neuroendocrine Tumor	Esophageal Neuroendocrine Tumour Neuroendocrine Tumor Of Esophagus Neuroendocrine Tumour Of Oesophagus
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS09034	NAPSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAPSA	VGNC	VGNC:63723
Bos taurus	NAPSA	VGNC	VGNC:31886
Mus musculus	NAPSA	MGD	MGI:109365
Canis familiaris	NAPSA	VGNC	VGNC:43624
Rattus norvegicus	NAPSA	RGD	RGD:61940
Others	NAPSA	NCBI