NAPSA - napsin A aspartic peptidase Gene

Homo sapiens

Also known as KAP; Kdap; NAP1; NAPA; SNAPA

Gene ID: 9476 | Gene type: protein coding

About NAPSA

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,358,477-50,365,639 (from NCBI)

This gene has 7 transcripts (splice variants), 119 orthologues and 9 paralogues. Restricted expression toward lung (RPKM 393.9).

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation Peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

NAPSA Products(1)

mRNA	Protein	Name
NM_004851.3	NP_004842.1	napsin-A preproprotein

NAPSA Protein Structure

Asp

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

napsin-A

ASP4

Related Diseases

Diseases

Alias

Ovarian Clear Cell Adenofibroma

Adenocarcinoma

Adenocarcinomas	Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site	Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site	Adenocarcinoma Nos

Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium

Solid Adenocarcinoma With Mucin Production

Cervical Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Cervix Uteri

Cervical Endometrioid Adenocarcinoma

Endometrioid Carcinoma Of The Cervix Uteri

Ureter Squamous Cell Carcinoma

Ureteral Epidermoid Carcinoma

Pleomorphic Carcinoma

Krukenberg Carcinoma

Krukenberg Tumor	Krukenberg Neoplasm
Krukenberg'S Tumor

Bladder Clear Cell Adenocarcinoma

Bladder Mesonephric Adenocarcinoma

Clear Cell Adenocarcinoma Of Bladder

Lung Giant Cell Carcinoma

Carcinoma, Giant Cell	Giant Cell Carcinoma
Giant Cell Lung Carcinoma	Carcinoma Giant Cell
Giant Cell Carcinoma Of Lung

Clear Cell Adenofibroma

Cystadenofibroma

Papillary Adenoma

Glandular Papilloma

Adenoma

Lung Combined Type Small Cell Carcinoma

Combined Small Cell Carcinoma Of The Lung

Combined Type Small Cell Carcinoma Of Lung

Lung Large Cell Carcinoma

Large Cell Carcinoma Of Lung	Large Cell Lung Carcinoma
Large Cell Lung Cancer

Non-Invasive Bladder Urothelial Carcinoma

Stage 0 Bladder Urothelial Carcinoma

Large Cell Neuroendocrine Carcinoma

Papillary Adenofibroma

Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus

Lung Sarcomatoid Carcinoma

Sarcomatoid Carcinoma Of The Lung

Pulmonary Sarcomatoid Carcinoma

Bladder Adenocarcinoma

Adenocarcinoma Of Bladder	Adenocarcinoma Of The Urinary Bladder
Bladder Adenocarcinoma, Not Otherwise Specified	Adenocarcinoma Bladder

Cervical Mucinous Adenocarcinoma

Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma	Mucin-Secreting Adenocarcinoma
Mucin-Secreting Carcinoma	Mucous Carcinoma
Pseudomyxoma Peritonei With Unknown Primary Site	Adenocarcinoma, Mucinous

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Pulmonary Large Cell Neuroendocrine Carcinoma

Large Cell Lung Neuroendocrine Carcinoma

Mucinous Lung Adenocarcinoma

Trigonitis

Bladder Trigonitis

Pseudomembranous Trigonitis

Ovarian Endodermal Sinus Tumor

Endodermal Sinus Tumor Of Ovary	Ovarian Yolk Sac Tumor
Endodermal Sinus Tumour Of Ovary	Ovarian Endodermal Sinus Tumour
Ovarian Yolk Sac Tumour

Respiratory System Benign Neoplasm

Bronchial Benign Neoplasm

Bronchus Neoplasm	Neoplasm Of Bronchus
Bronchial Neoplasms	Bronchial Neoplasm

Adenofibroma

Adenocarcinoma In Situ

Lung Clear Cell Carcinoma

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Ovarian Primitive Germ Cell Tumor

Basaloid Squamous Cell Carcinoma

Basaloid Carcinoma

Clear Cell Adenocarcinoma

Mesonephroma	Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell	Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma	Mesonephroma, Malignant
Water-Clear Cell Carcinoma	Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell	Mesonephric Tumor

Keratinizing Squamous Cell Carcinoma

Squamous Cell Carcinoma, Keratinizing

Keratinizing Epidermoid Carcinoma

Papillary Adenocarcinoma

Infiltrating And Papillary Adenocarcinoma	Infiltrating Papillary Adenocarcinoma
Adenocarcinoma Papillary	Adenocarcinoma, Papillary

Ovarian Clear Cell Carcinoma

Clear-Cell Ovarian Carcinoma

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour	Neuroendocrine Tumor Of Esophagus
Neuroendocrine Tumour Of Oesophagus

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Serous Cystadenocarcinoma

Serous Adenocarcinoma	Cystadenocarcinoma, Serous
Serous Carcinoma	Cystadenocarcinoma Serous

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09034	NAPSA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAPSA	VGNC	VGNC:63723
Bos taurus	NAPSA	VGNC	VGNC:31886
Mus musculus	NAPSA	MGD	MGI:109365
Canis familiaris	NAPSA	VGNC	VGNC:43624
Rattus norvegicus	NAPSA	RGD	RGD:61940