NAPSA - napsin A aspartic peptidase Gene

Also Known as KAP; Kdap; NAP1; NAPA; SNAPA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9476

About NAPSA

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,358,477-50,365,639 (from NCBI)

This gene has 7 transcripts (splice variants), 119 orthologues and 9 paralogues. Restricted expression toward lung (RPKM 393.9).

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

NAPSA Products (1)

mRNA Protein Name
NM_004851.3 NP_004842.1 napsin-A preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
14766755 GOA
enables peptidase activity IDA
IDA: Inferred from direct assay
18216060 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in membrane protein proteolysis IDA
IDA: Inferred from direct assay
14766755 GOA
involved in surfactant homeostasis IDA
IDA: Inferred from direct assay
18216060 GOA
Cellular Component GO Annotation Evidence References Source
located in alveolar lamellar body IDA
IDA: Inferred from direct assay
18216060 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
18216060 GOA
located in lysosome IDA
IDA: Inferred from direct assay
14766755 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPSA Protein Structure

Asp

Asp: Eukaryotic aspartyl protease (77 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

napsin-A

  • ASP4

NAPSA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NAPSA O96009 LCE1B Homo sapiens Q5T7P3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NAPSA Antibodies

Cat. No. Product Name Application Reactivity
HY-P81885 Napsin A Antibody (YA1630) WB, IHC-P, IP Human
HY-P83883 Napsin A Antibody (YA3580) WB, IHC-P, ELISA Human, Rat
HY-P83883A Napsin A Antibody (YA3580)(PBS only) WB, IHC-P, ELISA Human, Rat
HY-P85849 Napsin A Antibody (YA5541) IHC-P, WB, ICC/IF, ELISA Human
HY-P86021 Napsin A Antibody (YA5713) IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Ovarian Clear Cell Adenofibroma
Adenocarcinoma

  • Adenocarcinomas

  • Adenoacanthoma Of Unspecified Site

  • Adenocarcinoid Of Unspecified Site

  • Adenocarcinoid Tumour Of Unspecified Site

  • Adenocarcinoma And Carcinoid Combined Of Unspecified Site

  • Adenocarcinoma Nos
Endometrial Clear Cell Adenocarcinoma

  • Clear Cell Carcinoma Of Endometrium
Solid Adenocarcinoma With Mucin Production
Cervical Clear Cell Adenocarcinoma

  • Clear Cell Carcinoma Of The Cervix Uteri
Cervical Endometrioid Adenocarcinoma

  • Endometrioid Carcinoma Of The Cervix Uteri
Ureter Squamous Cell Carcinoma

  • Ureteral Epidermoid Carcinoma
Pleomorphic Carcinoma
Krukenberg Carcinoma

  • Krukenberg Tumor

  • Krukenberg Neoplasm

  • Krukenberg'S Tumor
Bladder Clear Cell Adenocarcinoma

  • Bladder Mesonephric Adenocarcinoma

  • Clear Cell Adenocarcinoma Of Bladder
Lung Giant Cell Carcinoma

  • Carcinoma, Giant Cell

  • Giant Cell Carcinoma

  • Giant Cell Lung Carcinoma

  • Carcinoma Giant Cell

  • Giant Cell Carcinoma Of Lung
Clear Cell Adenofibroma

  • Cystadenofibroma
Papillary Adenoma

  • Glandular Papilloma

  • Adenoma
Lung Combined Type Small Cell Carcinoma

  • Combined Small Cell Carcinoma Of The Lung

  • Combined Type Small Cell Carcinoma Of Lung
Lung Large Cell Carcinoma

  • Large Cell Carcinoma Of Lung

  • Large Cell Lung Carcinoma

  • Large Cell Lung Cancer
Non-Invasive Bladder Urothelial Carcinoma

  • Stage 0 Bladder Urothelial Carcinoma
Large Cell Neuroendocrine Carcinoma
Papillary Adenofibroma
Bronchus Adenoma

  • Bronchial Adenoma

  • Adenoma Of The Bronchus
Lung Sarcomatoid Carcinoma

  • Sarcomatoid Carcinoma Of The Lung

  • Pulmonary Sarcomatoid Carcinoma
Bladder Adenocarcinoma

  • Adenocarcinoma Of Bladder

  • Adenocarcinoma Of The Urinary Bladder

  • Bladder Adenocarcinoma, Not Otherwise Specified

  • Adenocarcinoma Bladder
Cervical Mucinous Adenocarcinoma
Mucinous Adenocarcinoma

  • Mucin-Producing Adenocarcinoma

  • Mucin-Secreting Adenocarcinoma

  • Mucin-Secreting Carcinoma

  • Mucous Carcinoma

  • Pseudomyxoma Peritonei With Unknown Primary Site

  • Adenocarcinoma, Mucinous
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Pulmonary Large Cell Neuroendocrine Carcinoma

  • Large Cell Lung Neuroendocrine Carcinoma
Mucinous Lung Adenocarcinoma
Trigonitis

  • Bladder Trigonitis

  • Pseudomembranous Trigonitis
Ovarian Endodermal Sinus Tumor

  • Endodermal Sinus Tumor Of Ovary

  • Ovarian Yolk Sac Tumor

  • Endodermal Sinus Tumour Of Ovary

  • Ovarian Endodermal Sinus Tumour

  • Ovarian Yolk Sac Tumour
Respiratory System Benign Neoplasm
Bronchial Benign Neoplasm

  • Bronchus Neoplasm

  • Neoplasm Of Bronchus

  • Bronchial Neoplasms

  • Bronchial Neoplasm
Adenofibroma
Adenocarcinoma In Situ
Lung Clear Cell Carcinoma
Parotid Gland Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Parotid Gland
Small Cell Carcinoma

  • Small Cell Carcinoma, Intermediate Cell

  • Intermediate Cell Small Cell Carcinoma

  • Small Cell Carcinoma - Intermediate Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Ovarian Primitive Germ Cell Tumor
Basaloid Squamous Cell Carcinoma

  • Basaloid Carcinoma
Clear Cell Adenocarcinoma

  • Mesonephroma

  • Water-Clear Cell Adenocarcinoma

  • Adenocarcinoma, Clear Cell

  • Malignant Mesonephroma

  • Mesonephroid Clear Cell Carcinoma

  • Mesonephroma, Malignant

  • Water-Clear Cell Carcinoma

  • Wolffian Duct Neoplasm

  • Adenocarcinoma Clear Cell

  • Mesonephric Tumor
Keratinizing Squamous Cell Carcinoma

  • Squamous Cell Carcinoma, Keratinizing

  • Keratinizing Epidermoid Carcinoma
Papillary Adenocarcinoma

  • Infiltrating And Papillary Adenocarcinoma

  • Infiltrating Papillary Adenocarcinoma

  • Adenocarcinoma Papillary

  • Adenocarcinoma, Papillary
Ovarian Clear Cell Carcinoma

  • Clear-Cell Ovarian Carcinoma
Large Cell Carcinoma

  • Carcinoma, Large Cell

  • Carcinoma Large Cell
Esophageal Neuroendocrine Tumor

  • Esophageal Neuroendocrine Tumour

  • Neuroendocrine Tumor Of Esophagus

  • Neuroendocrine Tumour Of Oesophagus
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Serous Cystadenocarcinoma

  • Serous Adenocarcinoma

  • Cystadenocarcinoma, Serous

  • Serous Carcinoma

  • Cystadenocarcinoma Serous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09034 NAPSA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NAPSA VGNC VGNC:63723
Bos taurus NAPSA VGNC VGNC:31886
Mus musculus NAPSA MGD MGI:109365
Canis familiaris NAPSA VGNC VGNC:43624
Rattus norvegicus NAPSA RGD RGD:61940
Others NAPSA NCBI