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Referencia número: HY-N19181

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Hancockiamide D

Hancockiamide D is a phenylpropanoid piperazine alkaloid found in the Australian soil fungus Aspergillus hancockii. Hancockiamide D induces cytotoxic activity in cancer cells and shows no activity in fibroblasts. Hancockiamide D can be used for the research of murine myeloma.

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No. CAS: 2758265-37-9
Fòrmula: C₂₀H₂₆N₂O₃
Peso molecular:342.44

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hancockiamide D Chemical Structure

No. CAS: 2758265-37-9

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

Hancockiamide D (compound 4) undergoes N-trans-cinnamoylation catalyzed by the single-module nonribosomal peptide synthetase Hkm11 in vitro to produce Hancockiamide A; the cytochrome P450 Hkm5 converts a portion of Hancockiamide D into H^[1].
Hancockiamide D exhibits potent cytotoxic activity against mouse myeloma NS-1 cells (MIC = 3.1 μg/mL), while showing no activity against neonatal foreskin fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2758265-37-9
Peso molecular 342.44
Fòrmula C₂₀H₂₆N₂O₃
SMILES

C(C1=CC(OC)=C(O)C(OC)=C1)[C@H]2CN[C@@H](CC3=CC=CC=C3)CN2
Structure Classification
- Others
Initial Source
- Microorganisms
Aspergillus hancockii
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Li H, et al. Hancockiamides: phenylpropanoid piperazines from Aspergillus hancockii are biosynthesised by a versatile dual single-module NRPS pathway. Organic & Biomolecular Chemistry. 2021;19(3):587-595.

Calculators

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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