Ilicicolin A
Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer.
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- No. CAS: 22581-06-2
- Fòrmula: C23H31ClO3
- Peso molecular:390.94
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) induces apoptosis in 22Rv1, C4-2B cells[1].
Ilicicolin A (0, 2.5, 5, 10 µM) inhibits cell growth and colony formation in 22Rv1 cells and C4-2B cells in a dose-dependent manner[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the protein expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1[1].
Ilicicolin A (0, 2.5, 5, 10 µM; 48 h) decreases the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:22Rv1, C4-2B cells
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Concentration:0, 2.5, 5, 10 µM
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Incubation Time:96 h
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Result:Inhibited cell growth in a dose-dependent manner.
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Cell Line:22Rv1, C4-2B cells
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Concentration:0, 2.5, 5, 10 µM
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Incubation Time:48 h
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Result:Induced apoptosis and increased the expression of cleaved-PARP1 and cleaved caspase 7.
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Cell Line:22Rv1, C4-2B cells
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Concentration:0, 2.5, 5, 10 µM
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Incubation Time:48 h
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Result:Decreased the expression of EZH2, AURKA, PLK1, FoxM1, Cyclin B2, AR, c-Myc, cyclin D1.
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Cell Line:22Rv1, C4-2B cells
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Concentration:0, 2.5, 5, 10 µM
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Incubation Time:48 h
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Result:Decreased the mRNA expression of AR, ALK2, ALK3 in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old, 18 g, male NOD/SCID mice (22Rv1 cells) [1]
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Dosage:10 mg/kg
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Administration:I.p.; six times a week for 3 weeks
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Result:Suppressed tumor growth but did not elicit a significant effect on bodyweight.
Chemical Information
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No. CAS 22581-06-2
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Peso molecular 390.94
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Fòrmula C23H31ClO3
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SMILES
O=CC1=C(C(C/C=C(CC/C=C(CC/C=C(C)\C)\C)\C)=C(C(Cl)=C1C)O)O
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Synonyms
LL-Z 1272-alpha
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Structure Classification
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Initial Source
Fusarium sp.
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ilicicolin A Related Classifications
HY-122108 Related Classifications
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