Maresin 1
Based on 6 publication(s) in Google Scholar
Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity.
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- Pureza: 99.03%
- No. CAS: 1268720-28-0
- Fòrmula: C22H32O4
- Peso molecular:360.49
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Maresin 1
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Actividad biológica
Maresin 1 (MaR1, 300 nM) reduces neutrophil migration and reactive oxygen species production, besides decreasing IL-1b, TNF-a, IL-6, and INF-g production[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Neutrophils (2×105 cells/well).
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Concentration:300 nM.
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Incubation Time:30 min.
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Result:Adherent cells are stimulated for 24 h with LPS (1 mg/ml) in the presence or absence of MaR1 (300 nM) in a final volume of 250 ml/well[3].
? Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, e.v.) protects mice against acute DSS-induced colitis. Maresin 1 (0.3, and 1 μg/animal, e.v.) treatment markedly reduces macroscopic damage in the acute protocol of DSS-induced colitis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CD1 mice (8-10 wk of age) (colitis was induced by DSS)[3].
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Dosage:0.1, 0.3, and 1 μg/animal.
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Administration:Intraocular route once a day from day 0 to day 7.
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Result:MaR1 (0.3 and 1 mg/animal) significantly reduces MPO levels in mouse colon tissue.
Chemical Information
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No. CAS 1268720-28-0
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Appearance Liquid
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Peso molecular 360.49
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Fòrmula C22H32O4
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Color Colorless to light yellow
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SMILES
CC/C=C\C/C=C\C[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\CCC(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Tailored Porous Bimetallic Nanozyme Platform for Full-Cycle Therapeutics of Intestinal Ischemia/Reperfusion. [Abstract]2026 Mar 31:e20748. PMID: 41915846 -
Biochem Pharmacol
Maresin1 ameliorates osseointegration in type 2 diabetes mellitus by promoting FAM134B-mediated ER-phagy in osteoblasts. [Abstract]2025 Oct:240:117099. PMID: 40619017 -
J Inflamm
MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway. [Abstract]2021 Feb 8;18(1):8. PMID: 33557833 -
J Inflamm Res
Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury. [Abstract]2024 Dec 13:17:11041-11053. PMID: 39691306 -
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Exp Ther Med
Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells. [Abstract]2026 Mar 19;31(5):141. PMID: 41929533
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Markus V Olsen, et al. Maresin 1, a Specialized Proresolving Mediator, Stimulates Intracellular [Ca 2+ ] and Secretion in Conjunctival Goblet Cells. J Cell Physiol. 2020 Jun 8. [Content Brief]
[2]. Macrophage Proresolving Mediator Maresin 1 Stimulates Tissue Regeneration and Controls Pain [Content Brief]
[3]. Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191(8):4288-98. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Maresin 1 Related Classifications
HY-116429 Related Classifications
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