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United States

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Referencia número: HY-W1048558A

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mPEG2000-CM

(Synonyms: mPEG2000-COOH)

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Based on 1 Customer Validation

mPEG2000-CM (mPEG2000-COOH) is a carboxyl-terminated monomethoxy polyethylene glycol. mPEG2000-CM bears a reactive carboxyl group (-COOH) at its structural terminal site, which can form stable amide bonds with amino groups and ester bonds with hydroxyl groups. mPEG2000-CM binds to PCA-g-PCL copolymers via electrostatic interaction to form polyion complex micelles with a hydrophilic PEG surface, which enhances the stability of micelles in aqueous media. mPEG2000-CM can be used for drug delivery.

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Pureza: 99.96%
Peso molecular:2000 (Average)

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

mPEG2000-CM Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

In Vitro

mPEG2000-CM (5 h at 150 °C) is successfully synthesized by reacting poly(ethylene glycol) methyl ether (Mn = 1900) with succinic anhydride at 150 °C for 5 h, followed by purification via double precipitation^[1].
mPEG2000-CM (0.2:1-1:1 feed molar ratio to PCA-g-PCL; 1 h mixed) conjugates with PCA-g-PCL via electrostatic interaction to form spherical polyion complex micelles, where higher mPEG-COOH to PCA-g-PCL molar ratios produce smaller micelles, and mPEG@PCA-g-PCL(1:1) micelles load paclitaxel with 7.8% drug loading and 78.6% encapsulation efficiency^[1].
mPEG2000-CM (0.2 g starch; 0.38 g mPEG-CM; 0.144 g EDC·HCl; 0.046 g DMAP in 15 mL DMSO; 48 h at 25 °C; 3 days (dialysis)) conjugated to soluble starch via EDC·HCl/DMAP coupling in DMSO at 25 °C for 48 h produces mPEGylated starch (mPEG-St) with a 76.4% yield^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Peso molecular 2000 (Average)
Color White to off-white
SMILES

COCCOCC(O)=O.[n]
Synonyms

mPEG2000-COOH
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Huang H, et al. Fabrication and reduction-sensitive behavior of polyion complex nano-micelles based on PEG-conjugated polymer containing disulfide bonds as a potential carrier of anti-tumor paclitaxel. Colloids Surf B Biointerfaces. 2013;110:59-65. [Content Brief]

[2].
Jinlong Yang, et al. Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery. \tRSC Adv., 2014,4, 55139-55149.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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