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Referencia número: HY-126452

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NLCQ-1

(Synonyms: NSC 709257)

NLCQ-1 (NSC 709257) is an orally active antibacterial agent targeting dormant Mycobacterium tuberculosis. NLCQ-1 is promising for research of tuberculosis.

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No. CAS: 221292-08-6
Fòrmula: C₁₅H₁₅Cl₂N₅O₂
Peso molecular:368.22

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NLCQ-1 Chemical Structure

No. CAS: 221292-08-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

NLCQ-1 (NSC 709257) is an orally active antibacterial agent targeting dormant Mycobacterium tuberculosis. NLCQ-1 is promising for research of tuberculosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	1.041 μM Compound: 5	Antitrypanosomal activity against blood stream form of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells after 72 hrs by alamar blue assay Antitrypanosomal activity against blood stream form of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22023653]
L6	IC₅₀	1.397 μM Compound: 5	Antitrypanosomal activity against blood stream form of Trypanosoma brucei rhodesiense STIB 900 infected in rat L6 cells after 72 hrs by alamar blue assay Antitrypanosomal activity against blood stream form of Trypanosoma brucei rhodesiense STIB 900 infected in rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22023653]
L6	IC₅₀	24.95 μM Compound: 5	Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22023653]
L6	IC₅₀	25 μM Compound: NLCQ-1	Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 2 days by cell-titer-glo luminescent assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability after 2 days by cell-titer-glo luminescent assay	[PMID: 28763645]
L6	IC₅₀	54.35 μM Compound: 5	Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes infected in rat L6 cells after 72 hrs by alamar blue assay Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes infected in rat L6 cells after 72 hrs by alamar blue assay	[PMID: 22023653]

Chemical Information

No. CAS 221292-08-6
Peso molecular 368.22
Fòrmula C₁₅H₁₅Cl₂N₅O₂
SMILES

O=[N+](C1=NC=CN1CCCNC2=CC=NC3=CC(Cl)=CC=C23)[O-].Cl
Synonyms

NSC 709257
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Papadopoulou MV, et al. NLCQ-1 and NLCQ-2, two new agents with activity against dormant Mycobacterium tuberculosis. Int J Antimicrob Agents. 2007 Jun;29(6):724-7. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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