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Referencia número: HY-P10404

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PDpep1.3

PDpep1.3 is a peptide inhibitor of α-synuclein that disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). As a result, PDpep1.3 restores the degradation function of endosomes and lysosomes, reduces the protein level and aggregation of α-synuclei, and protects dopaminergic neurons from α-synuclei-mediated degeneration. PDpep1.3 can be used to study neurodegenerative diseases and protein-protein interactions.

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No. CAS: 2942277-55-4
Fòrmula: C₅₉H₁₀₁N₁₇O₂₂
Peso molecular:1400.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDpep1.3 Chemical Structure

No. CAS: 2942277-55-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

α-synuclein Aggregation

α-synuclein/CHMP2B

Ver todos los productos específicos de isoformas α-synuclein :

Chemical Information

No. CAS 2942277-55-4
Peso molecular 1400.53
Fòrmula C₅₉H₁₀₁N₁₇O₂₂
Sequence

Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly
Sequence Shortening

DEEIERQLKALG
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Nim S, et al. Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease[J]. Nature Communications, 2023, 14(1): 2150. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PDpep1.3

Ver todos los productos específicos de isoformas α-synuclein

Actividad biológica

Chemical Information

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Referencias

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PDpep1.3 Related Classifications

HY-P10404 Related Classifications