Prostaglandin G2
Based on 1 Customer Validation
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A2 production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury.
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- Pureza: 99.9%
- No. CAS: 51982-36-6
- Fòrmula: C20H32O6
- Peso molecular:368.46
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Prostaglandin G2 (0.6-1 μg) incubated with Indomethacin (HY-14397)-pretreated washed human platelets generates an unstable rabbit aorta contracting factor (thromboxane A2) with a half-life of 34 sec at 37 °C that induces strong contraction of isolated rabbit aorta strips[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic cats (anesthetized with pentobarbital)[2]
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Dosage:10 μg/mL
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Administration:topical application under cranial window; single 15-minute exposure
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Result:Induced 30% residual arteriolar dilation (percent of control) 1 hour after removal.
Reduced arteriolar diameter decrease in response to arterial hypocapnia from 12% to 8% of control.
Caused 13.3 endothelial lesions per 2100 μm2 of pial arteriole surface.
Chemical Information
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No. CAS 51982-36-6
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Appearance Liquid
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Peso molecular 368.46
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Fòrmula C20H32O6
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Color Colorless to light yellow
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SMILES
CCCCC[C@H](OO)/C=C/[C@@H]1[C@H]([C@]2([H])C[C@@]1([H])OO2)C/C=C\CCCC(O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Prostaglandin G2 Related Classifications
HY-116778 Related Classifications
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- Prostaglandin G2
- 51982-36-6
- Prostaglandin G 2
- Prostaglandin G-2
- Reactive Oxygen Species (ROS)
- free oxygen radical generation
- thromboxane B2
- human platelets
- guinea pig lung
- superoxide dismutase
- thromboxane A2
- anesthetized cats
- rabbit aorta contracting substance
- cerebral arteriolar damage
- thromboxanes
- Inhibitor
- inhibitor
- inhibit