SDUY127
SDUY127 is a bivalent SHP2 inhibitor with an IC50 value of 16 nM. SDUY127 binds simultaneously to the tunnel allosteric site and latch allosteric site of SHP2 at a 1:1 stoichiometric ratio, stabilizes the protein in an inactive conformation, and induces sustained inhibition of the MAPK signaling pathway. SDUY127 can be used in research related to leukemia and hepatocellular carcinoma.
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- Fòrmula: C58H69Cl2N13O9S
- Peso molecular:1195.22
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
SDUY127 (1-3 μM; 48 h) inhibits MV4-11 leukemia cell proliferation by 33% at 1 μM and 79% at 3 μM after 48 h of treatment[1].
SDUY127 (10-30 μM; 48 h) inhibits Hep3B hepatocellular carcinoma cell proliferation by 23% at 10 μM and 84% at 30 μM after 48 h of treatment[1].
SDUY127 (3 μM; 15 min; 2 h) induces sustained suppression of ERK phosphorylation in MV4-11 cells, maintaining ~76% inhibition at 2 h post-treatment[1].
SDUY127 (3 μM; 15 min; 2 h) induces transient suppression of ERK phosphorylation in Hep3B cells, with inhibition decreasing from ~76% at 15 min to ~48% at 2 h post-treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 leukemia cells
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Concentration:3 μM
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Incubation Time:15 min; 2 h
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Result:Suppressed pERK levels by ~79% at 15 min.
Maintained pERK suppression at ~76% at 2 h.
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Cell Line:Hep3B hepatocellular carcinoma cells
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Concentration:3 μM
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Incubation Time:15 min; 2 h
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Result:Suppressed pERK levels by ~76% at 15 min.
Decreased pERK inhibition to ~48% at 2 h.
Chemical Information
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Peso molecular 1195.22
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Fòrmula C58H69Cl2N13O9S
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SMILES
COC1=C(C=CC=C1C(N2C3=C4C=CC=C3)=NN=C2N(C4=O)CC5=CC=CC=C5Cl)OCCOCCOCCOCCN6CCN(CC6)C(CCCNC(CC(NC7=CC=CC(SC8=C(N)N=C(N9CCC(C)(CC9)N)C=N8)=C7Cl)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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