Syk-IN-8
Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers.
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- No. CAS: 2568963-01-7
- Fòrmula: C23H26N10
- Peso molecular:442.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Daudi | IC50 |
719 nM
Compound: 19q
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Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37423126] |
| DOHH-2 | IC50 |
8.68 nM
Compound: 19q
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Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37423126] |
| MV4-11 | IC50 |
1.5 nM
Compound: 19q
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Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay
Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37423126] |
| Ramos | IC50 |
18 nM
Compound: 19q
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Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins
Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins
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[PMID: 37423126] |
| Rec1 | IC50 |
34.3 nM
Compound: 19q
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Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37423126] |
| SU-DHL-6 | IC50 |
216 nM
Compound: 19q
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Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37423126] |
| TMD8 | IC50 |
10.9 nM
Compound: 19q
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Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37423126] |
Chemical Information
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No. CAS 2568963-01-7
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Peso molecular 442.52
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Fòrmula C23H26N10
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SMILES
CC(C)N1CCN(CC1)C2=CC=C3N=C(NC3=C2)C4=NNC=C4NC5=C6C(NC=C6)=NC=N5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Syk-IN-8 Related Classifications
HY-155513 Related Classifications
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