W-GTF01
W-GTF01 is a MGAT1 inhibitor. W-GTF01 blocks the MGAT1-catalyzed glycosylation of CD73, and inhibits CD73 dimerization, membrane translocation and adenosine production. W-GTF01 restores the function of IFNγ-producing CD8+ T cells, enhances tumor infiltration and activation of CD8+ T cells, and suppresses tumor growth. W-GTF01 can be used in research related to triple-negative breast cancer.
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- No. CAS: 951968-89-1
- Fòrmula: C24H20N2O5
- Peso molecular:416.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
W-GTF01 restores tumor immune response in immunosuppressive breast cancer cells and reduces CD73 membrane localization in MDA-MB468 and MDA-MB231 triple-negative breast cancer (TNBC) cells by blocking MGAT1-mediated CD73 glycosylation[1].
W-GTF01 potently and dose-dependently inhibits MGAT1 enzymatic activity via specific binding to the MGAT1 active site[2].
W-GTF01 revives CD8+ effector T cell function (including IFNγ production) and reduces MDA-MB468 TNBC cell survival in a CD73-dependent manner in 2D coculture with PBMCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/C (female; syngeneic triple-negative breast cancer model with 4T1-hPD-L1 cells injected subcutaneously into mammary fat pad)[2]
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Dosage:5 mg/kg
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Administration:i.p.; twice per week
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Result:Exhibited enhanced tumor growth suppression relative to single treatments.
Prominently improved survival outcomes compared with monotherapy and control groups.
Markedly elevated CD8+ T cell infiltration and activation and mitigated T cell exhaustion versus anti-PD-L1 antibody alone.
Chemical Information
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No. CAS 951968-89-1
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Peso molecular 416.43
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Fòrmula C24H20N2O5
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SMILES
O=C(C1=CC(OCO2)=C2C=C1)NC3=CC(C4=NC5=C(C=C(C)C(C)=C5)O4)=C(O)C(C)=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
W-GTF01 Related Classifications
HY-185701 Related Classifications
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