951968-89-1
951968-89-1
Chemical Structure
W-GTF01
- CAS No.: 951968-89-1
- Formula:C24H20N2O5
- Molecular Weight:416.43
InChIKey: AXMOWDVCAUUTIN-UHFFFAOYSA-N
SMILES: O=C(C1=CC(OCO2)=C2C=C1)NC3=CC(C4=NC5=C(C=C(C)C(C)=C5)O4)=C(O)C(C)=C3
Biological Activity: W-GTF01 is a MGAT1 inhibitor. W-GTF01 blocks the MGAT1-catalyzed glycosylation of CD73, and inhibits CD73 dimerization, membrane translocation and adenosine production. W-GTF01 restores the function of IFNγ-producing CD8+ T cells, enhances tumor infiltration and activation of CD8+ T cells, and suppresses tumor growth. W-GTF01 can be used in research related to triple-negative breast cancer[1][2].
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W-GTF01 | W-GTF01 is a MGAT1 inhibitor. W-GTF01 blocks the MGAT1-catalyzed glycosylation of CD73, and inhibits CD73 dimerization, membrane translocation and adenosine production. W-GTF01 restores the function of IFNγ-producing CD8+ T cells, enhances tumor infiltration and activation of CD8+ T cells, and suppresses tumor growth. W-GTF01 can be used in research related to triple-negative breast cancer. | |||||||||||||||||||||
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References
- [1]. Chi J. MGAT1-Mediated Glycosylation Orchestrates Immune Checkpoints and Antitumor Immunity. Clin Cancer Res. 2025 Jun 15;31:P2-06-12.
- [2]. Chi JJ, et al. MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer. Nat Commun. 2025;16(1):3552. Published 2025 Apr 15. [Content Brief]
